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Current Alzheimer Research

Editor-in-Chief

ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

Intra and Extracellular Protein Interactions with Tau

Author(s): F. Hernandez and J. Avila

Volume 7, Issue 8, 2010

Page: [670 - 676] Pages: 7

DOI: 10.2174/156720510793611583

Price: $65

Abstract

Tau is a sticky protein mainly expressed by neurons, which may be found in different subcellular fractions or outside the cell. Tau is mainly associated to microtubules in the cytoplasm, although besides tubulin, tau can also bind to other proteins and to itself to form different polymers, some of which are relevant in pathological disorders. In this short review, we have revised some of the interactions involving tau, both inside or outside of the cell. Different regions of tau are involved in these interactions and some of them are more conserved throughout evolution than others.

Keywords: Alzheimer’s disease, extracellular tau protein, intracellular tau protein, tau protein evolution.


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