Abstract
P-glycoprotein (P-gp) at the blood-brain barrier (BBB) functions as an active efflux pump by extruding a wide range of substrates from the brain. This is important for maintaining loco-regional homeostasis and for protecting the brain against blood-borne toxic substances. Altered P-gp function seems to be involved in the pathophysiology of neurodegenerative disease and various neurological and psychiatric disorders. Positron emission tomography (PET) with the radiotracer 11C-verapamil (VPM-PET) is a validated technique allowing measurement of P-gp function at the human BBB. In this review, we highlight changes of P-gp function, as measured with VPM-PET, in aging and in the pathogenesis and progression of neurodegenerative disease, as well as their role in depressive disorders.
Keywords: P-glycoprotein, Blood-Brain Barrier, Ageing, Depression, Parkinson's Disease, Alzheimer's Disease, Positron Emission Tomography (PET), Verapamil, C-verapamil, P-glycoprotein (P-gp), Blood-brain barrier (BBB), (MRP), Central nervous system (CNS), Amyotrophic lateral sclerosis, Single-photon emission computed tomography, Tariquidar, P-gp expression, CD4+ and CD8+ T Cells, Statistical parametric mapping (SPM), Neurodegenerative disease, β-amyloid, ß-amyloid precursor protein (APP), ß-site APP cleaving enzyme (BACE), Lipoprotein receptor related protein 1 (LRP1), Cerebral amyloid angiopathy (CAA), P-gp inhibitor, Rifampicin, GSK188909, α-synuclein oligomers, C3435T TT polymorphism, Progressive supranuclear palsy (PSP), Multisystem atrophy (MSA), Pergolide, pramipexol, budipine, Huntington disease (HD), Creutzfeldt-Jakob Disease (CJD), Amyotrophic lateral sclerosis (ALS), Major depressive disorder (MDD)
Current Topics in Medicinal Chemistry
Title: 11C-verapamil to Assess P-gp Function in Human Brain During Aging,Depression and Neurodegenerative Disease
Volume: 10 Issue: 17
Author(s): A. L. Bartels, O. L. de Klerk, R. Kortekaas, J. J. de Vries and K. L. Leenders
Affiliation:
Keywords: P-glycoprotein, Blood-Brain Barrier, Ageing, Depression, Parkinson's Disease, Alzheimer's Disease, Positron Emission Tomography (PET), Verapamil, C-verapamil, P-glycoprotein (P-gp), Blood-brain barrier (BBB), (MRP), Central nervous system (CNS), Amyotrophic lateral sclerosis, Single-photon emission computed tomography, Tariquidar, P-gp expression, CD4+ and CD8+ T Cells, Statistical parametric mapping (SPM), Neurodegenerative disease, β-amyloid, ß-amyloid precursor protein (APP), ß-site APP cleaving enzyme (BACE), Lipoprotein receptor related protein 1 (LRP1), Cerebral amyloid angiopathy (CAA), P-gp inhibitor, Rifampicin, GSK188909, α-synuclein oligomers, C3435T TT polymorphism, Progressive supranuclear palsy (PSP), Multisystem atrophy (MSA), Pergolide, pramipexol, budipine, Huntington disease (HD), Creutzfeldt-Jakob Disease (CJD), Amyotrophic lateral sclerosis (ALS), Major depressive disorder (MDD)
Abstract: P-glycoprotein (P-gp) at the blood-brain barrier (BBB) functions as an active efflux pump by extruding a wide range of substrates from the brain. This is important for maintaining loco-regional homeostasis and for protecting the brain against blood-borne toxic substances. Altered P-gp function seems to be involved in the pathophysiology of neurodegenerative disease and various neurological and psychiatric disorders. Positron emission tomography (PET) with the radiotracer 11C-verapamil (VPM-PET) is a validated technique allowing measurement of P-gp function at the human BBB. In this review, we highlight changes of P-gp function, as measured with VPM-PET, in aging and in the pathogenesis and progression of neurodegenerative disease, as well as their role in depressive disorders.
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Cite this article as:
L. Bartels A., L. de Klerk O., Kortekaas R., J. de Vries J. and L. Leenders K., 11C-verapamil to Assess P-gp Function in Human Brain During Aging,Depression and Neurodegenerative Disease, Current Topics in Medicinal Chemistry 2010; 10 (17) . https://dx.doi.org/10.2174/156802610792928059
DOI https://dx.doi.org/10.2174/156802610792928059 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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