Estrone (E1) Based Esters as Potential Inhibitors of Type 3 17β- hydroxysteroid Dehydrogenase (17β-HSD3) in the Treatment of Hormone-Dependent Prostate Cancer

Moniola      S. Olusanjo; Sabbir      Ahmed

Abstract

We report the use of estrone (E1)-based compounds in the search for inhibitors of 17β-hydroxysteroid dehydrogenase, in particular, type 3 (17β-HSD3). Results suggest that the compounds are good inhibitors of 17β-HSD3 and a number were found to be equipotent to the standard inhibitors used within the current study.

Keywords: 17β-Hydroxysteroid dehydrogenase, Type 3, Inhibition, Enzyme, Steroid-based compound, Prostate cancer, Estrone, Potential Inhibitors, Estrone (E1)-based compounds, Type 3 (17bHSD3), Standard inhibitors, Biochemical target, Androgen-dependent cancer, Breast cancer, Ester-based derivatives, Non-radioactive steroids, Perkin-Elmer Fourier Transform Paragon, PET polyester, 17b-Hydroxysteroid dehydrogenase, Inhibitory activity, Cycloalkyl based compounds