Abstract
Nuclear factor-κB (NF-κB) is one of the most important transcription factors; it has a key role in inflammatory and immune responses, cell adhesion, developmental signals, and anti-apoptosis process. Inflammatory lung diseases such as asthma and chronic obstructive pulmonary disease (COPD) are major causes of morbidity and mortality worldwide. In this review, we highlight the role of NF-κB in inflammatory lung disease, the strategies which block the activation of NF- κB, and the therapeutic approaches to treating inflammatory lung disease.
Keywords: Asthma, cell adhesion, COPD, inflammatory lung disease, NF-κB, therapeutic approach
Inflammation & Allergy - Drug Targets (Discontinued)
Title: The Role of Nuclear Factor-κB in Inflammatory Lung Disease
Volume: 9 Issue: 3
Author(s): Abbas Ali Imanifooladi, Samaneh Yazdani and Mohammad Reza Nourani
Affiliation:
Keywords: Asthma, cell adhesion, COPD, inflammatory lung disease, NF-κB, therapeutic approach
Abstract: Nuclear factor-κB (NF-κB) is one of the most important transcription factors; it has a key role in inflammatory and immune responses, cell adhesion, developmental signals, and anti-apoptosis process. Inflammatory lung diseases such as asthma and chronic obstructive pulmonary disease (COPD) are major causes of morbidity and mortality worldwide. In this review, we highlight the role of NF-κB in inflammatory lung disease, the strategies which block the activation of NF- κB, and the therapeutic approaches to treating inflammatory lung disease.
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Cite this article as:
Imanifooladi Ali Abbas, Yazdani Samaneh and Nourani Reza Mohammad, The Role of Nuclear Factor-κB in Inflammatory Lung Disease, Inflammation & Allergy - Drug Targets (Discontinued) 2010; 9 (3) . https://dx.doi.org/10.2174/187152810792231904
DOI https://dx.doi.org/10.2174/187152810792231904 |
Print ISSN 1871-5281 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-4055 |
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