Abstract
Development of novel erythromycin-based antibiotics has been one of the most studied topics in the past three decades. Such tremendous efforts have generated a number of beneficiary drugs such as clarithromycin, azithromycin and telithromycin. However, widespread application of antibiotics in clinical practice has triggered an increasing emergence of bacterial resistance. Therefore, discovery of novel macrolide antibiotics to suppress the resistance is urgent for human healthcare. This review focuses on advances in the area since 2004.
Keywords: Macrolide antibiotics, erythromycin, SAR, antibacterial
Current Topics in Medicinal Chemistry
Title: Recent Advances in the Medicinal Chemistry of Novel Erythromycin- Derivatized Antibiotics
Volume: 10 Issue: 14
Author(s): Lu Ying and Datong Tang
Affiliation:
Keywords: Macrolide antibiotics, erythromycin, SAR, antibacterial
Abstract: Development of novel erythromycin-based antibiotics has been one of the most studied topics in the past three decades. Such tremendous efforts have generated a number of beneficiary drugs such as clarithromycin, azithromycin and telithromycin. However, widespread application of antibiotics in clinical practice has triggered an increasing emergence of bacterial resistance. Therefore, discovery of novel macrolide antibiotics to suppress the resistance is urgent for human healthcare. This review focuses on advances in the area since 2004.
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Cite this article as:
Ying Lu and Tang Datong, Recent Advances in the Medicinal Chemistry of Novel Erythromycin- Derivatized Antibiotics, Current Topics in Medicinal Chemistry 2010; 10 (14) . https://dx.doi.org/10.2174/156802610792232042
DOI https://dx.doi.org/10.2174/156802610792232042 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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