Abstract
Solid tumors require angiogenesis for their growth and to form metastatsis. Many new cancer therapies are directed against tumor vessels. Radiation therapy is one of the most widely used treatments for a wide variety of tumors, and is thought to act by directly targeting clongenes, as well as was induce apoptosis of endothelial cells, and reduce angiogenesis. Vascular targeting agents are aimed specifically at the existing tumor vasculature. Anti-angiogenic agents target angiogenesis or new growth of tumor vessels. Recent preclinical studies have suggested that radiotherapy in combination with antiangiogenic agents enhances the therapeutic ratio of ioninzing radiation alone. Targeting tumor vasculature has strong biological rationale in radiation therapy and preclinical studies consistently show an increase in radiationsensitization with combined treatment. This review article explores the complex interaction between radiation therapy and antiangiogenic agents. Furthermore we discuss the efficacy of combined radiotherapy and AT1-R antagonist (TCV-116) on tumor associated angiogenesis.
Keywords: Angiogenesis, radiationtherapy, anti-angiogenic agents, combination therapy, angiotensin type 1 receptor
Current Signal Transduction Therapy
Title: Combined Effect of Anti-Angiogentic Agents, Angiotensin Type 1 Receptor Antagonists and Radiation Therapy
Volume: 5 Issue: 3
Author(s): Hideki Amano, Yuichiro Ohnuma, Yuzuru Niibe, Kazushige Hayakawa, Yukitoshi Satoh and Masataka Majima
Affiliation:
Keywords: Angiogenesis, radiationtherapy, anti-angiogenic agents, combination therapy, angiotensin type 1 receptor
Abstract: Solid tumors require angiogenesis for their growth and to form metastatsis. Many new cancer therapies are directed against tumor vessels. Radiation therapy is one of the most widely used treatments for a wide variety of tumors, and is thought to act by directly targeting clongenes, as well as was induce apoptosis of endothelial cells, and reduce angiogenesis. Vascular targeting agents are aimed specifically at the existing tumor vasculature. Anti-angiogenic agents target angiogenesis or new growth of tumor vessels. Recent preclinical studies have suggested that radiotherapy in combination with antiangiogenic agents enhances the therapeutic ratio of ioninzing radiation alone. Targeting tumor vasculature has strong biological rationale in radiation therapy and preclinical studies consistently show an increase in radiationsensitization with combined treatment. This review article explores the complex interaction between radiation therapy and antiangiogenic agents. Furthermore we discuss the efficacy of combined radiotherapy and AT1-R antagonist (TCV-116) on tumor associated angiogenesis.
Export Options
About this article
Cite this article as:
Amano Hideki, Ohnuma Yuichiro, Niibe Yuzuru, Hayakawa Kazushige, Satoh Yukitoshi and Majima Masataka, Combined Effect of Anti-Angiogentic Agents, Angiotensin Type 1 Receptor Antagonists and Radiation Therapy, Current Signal Transduction Therapy 2010; 5 (3) . https://dx.doi.org/10.2174/157436210791920292
DOI https://dx.doi.org/10.2174/157436210791920292 |
Print ISSN 1574-3624 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-389X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Peptidergic Regulation of Pheochromocytoma
Current Pharmacogenomics The Structural Determinations of the Leucine Zipper Coiled-Coil Domains of the cGMP-Dependent Protein Kinase Iα and Its Interaction with the Myosin Binding Subunit of the Myosin Light Chains Phosphase
Protein & Peptide Letters Roles of IL-6-gp130 Signaling in Vascular Inflammation
Current Cardiology Reviews Plasma Angiotensin-(1-7) is a Potential Biomarker for Alzheimer’s Disease
Current Neurovascular Research Angiotensin Receptor Blockers in Chronic Heart Failure: Clinical Implications and Molecular Mechanisms
Current Cardiology Reviews The Use of Vitamin D in Respiratory Diseases
Current Respiratory Medicine Reviews Cardiovascular Risk Factors, Metabolic Complications, & the Natural Course of CKD in Children
Current Hypertension Reviews Expression and Functions of Vasoactive Substances Regulated by Hypoxia-Inducible Factor-1 in Chronic Hypoxemia
Cardiovascular & Hematological Agents in Medicinal Chemistry Green Aqueous Synthesis of Mono, Bis and Trisdihydropyridines Using Nano Fe<sub>3</sub>O<sub>4</sub> Under Ultrasound Irradiation
Current Organic Synthesis Obstructive Sleep Apnea and Cardiovascular Disease - A New Target for Treatment
Current Pharmaceutical Design Doxycycline Inhibition of Abdominal Aortic Aneurysm Growth - A Systematic Review of the Literature
Current Vascular Pharmacology Atrial Natriuretic Peptide: Structure, Function, and Physiological Effects: A Narrative Review
Current Cardiology Reviews Novel Therapeutic Targets for Phosphodiesterase 5 Inhibitors: current state-of-the-art on systemic arterial hypertension and atherosclerosis
Current Pharmaceutical Biotechnology New Approved Medications for Idiopathic Pulmonary Fibrosis
Current Drug Therapy Vitamin D and Vitamin D Receptor: New Insights in the Treatment of Hypertension
Current Protein & Peptide Science Potential Effect of Anti-Inflammatory Treatment on Reducing the Cardiovascular Risk in Rheumatoid Arthritis
Current Vascular Pharmacology The Inflammation Paradigm and Coronary Artery Disease: What Celsus, Virchow and Gene Knock Outs Have Taught Us
Cardiovascular & Hematological Disorders-Drug Targets In Search for the Troponin of the Kidney
Current Medicinal Chemistry Regulation of Angiogenesis and Angiogenic Factors by Cardiovascular Medications
Current Pharmaceutical Design The Nitric Oxide Pathway in Pulmonary Arterial Hypertension: Pathomechanism, Biomarkers and Drug Targets
Current Medicinal Chemistry