Abstract
Human Embryonic or pluripotent stem cells hold many promises in regenerative medicine. They also provide the scientific community with powerful models of early human development including cardiogenesis under normal or pathological (congenital and genetic diseases) situations. Furthermore their cardiac derivatives turn out to be very useful to study human cardiac electrophysiology, pharmacology or cardiac toxicology. The current overview provides the basic knowledge on developmental biology of the heart which can be applied to stem cell research to study early cardiogenesis. We summarize both the cardiogenic transcriptional network and the role of morphogens involved in early cardiogenesis. We review protocols of cardiac differentiation of pluripotent stem cells so far available. We finally discuss the translation of basic stem cell research into clinical applications.
Keywords: Cardiogenesis, development, heart, Oct4, progenitors, regenerative medecine, stem cells
Current Stem Cell Research & Therapy
Title: Human Embryonic and Induced Pluripotent Stem Cells in Basic and Clinical Research in Cardiology
Volume: 5 Issue: 3
Author(s): Guillaume Blin, Tui Neri, Sonia Stefanovic and Michel Puceat
Affiliation:
Keywords: Cardiogenesis, development, heart, Oct4, progenitors, regenerative medecine, stem cells
Abstract: Human Embryonic or pluripotent stem cells hold many promises in regenerative medicine. They also provide the scientific community with powerful models of early human development including cardiogenesis under normal or pathological (congenital and genetic diseases) situations. Furthermore their cardiac derivatives turn out to be very useful to study human cardiac electrophysiology, pharmacology or cardiac toxicology. The current overview provides the basic knowledge on developmental biology of the heart which can be applied to stem cell research to study early cardiogenesis. We summarize both the cardiogenic transcriptional network and the role of morphogens involved in early cardiogenesis. We review protocols of cardiac differentiation of pluripotent stem cells so far available. We finally discuss the translation of basic stem cell research into clinical applications.
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Cite this article as:
Blin Guillaume, Neri Tui, Stefanovic Sonia and Puceat Michel, Human Embryonic and Induced Pluripotent Stem Cells in Basic and Clinical Research in Cardiology, Current Stem Cell Research & Therapy 2010; 5 (3) . https://dx.doi.org/10.2174/157488810791824584
DOI https://dx.doi.org/10.2174/157488810791824584 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
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