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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Kv1.5-Kvβ Interactions: Molecular Determinants and Pharmacological Consequences

Author(s): Teresa Gonzalez, Miren David, Cristina Moreno, Alvaro Macias and Carmen Valenzuela

Volume 10, Issue 7, 2010

Page: [635 - 642] Pages: 8

DOI: 10.2174/138955710791384018

Price: $65

Abstract

Kv1.5 channels are homotetramers of α-pore subunits mainly present in human atrium and pulmonary vasculature. Thus, Kv1.5 is a pharmacological target for cardiovascular diseases. Kvβ1.3 assemblies with Kvα1.5 and modifies its gating and pharmacology. A further knowledge of α-β interactions and pharmacology will lead a better design of new drugs.

Keywords: Ion channels, Kv channels, Beta subunits, Kvβ1.3, Kv1.5, Bupivacaine


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