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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Bioactivity of Sesquiterpenes: Compounds that Protect from Alcohol-Induced Gastric Mucosal Lesions and Oxidative Damage

Author(s): M.G. Repetto and A. Boveris

Volume 10, Issue 7, 2010

Page: [615 - 623] Pages: 9

DOI: 10.2174/138955710791383992

Price: $65

Abstract

Sesquiterpene lactones of the guaianolide and eudermanolide types are considered of interest because they have an effect in the regulation and prevention of oxidative damage and inflammation-mediated biological damage. Dehydroleucodine, a natural sesquiterpene isolated from Artemisia douglasiana Besser, and ilicic aldehyde, a semi-synthetic sesquiterpene lactones, showed in vivo protection in ethanol-induced gastric mucosa damage. This action was determined by in situ gastric mucosa chemiluminescence and by tissue antioxidant content.

Keywords: Cytoprotection, dehydroleucodine, ethanol gastric damage, gastric ulcer, inflammation, sesquiterpene lactone


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