Abstract
Sesquiterpene lactones of the guaianolide and eudermanolide types are considered of interest because they have an effect in the regulation and prevention of oxidative damage and inflammation-mediated biological damage. Dehydroleucodine, a natural sesquiterpene isolated from Artemisia douglasiana Besser, and ilicic aldehyde, a semi-synthetic sesquiterpene lactones, showed in vivo protection in ethanol-induced gastric mucosa damage. This action was determined by in situ gastric mucosa chemiluminescence and by tissue antioxidant content.
Keywords: Cytoprotection, dehydroleucodine, ethanol gastric damage, gastric ulcer, inflammation, sesquiterpene lactone
Mini-Reviews in Medicinal Chemistry
Title: Bioactivity of Sesquiterpenes: Compounds that Protect from Alcohol-Induced Gastric Mucosal Lesions and Oxidative Damage
Volume: 10 Issue: 7
Author(s): M.G. Repetto and A. Boveris
Affiliation:
Keywords: Cytoprotection, dehydroleucodine, ethanol gastric damage, gastric ulcer, inflammation, sesquiterpene lactone
Abstract: Sesquiterpene lactones of the guaianolide and eudermanolide types are considered of interest because they have an effect in the regulation and prevention of oxidative damage and inflammation-mediated biological damage. Dehydroleucodine, a natural sesquiterpene isolated from Artemisia douglasiana Besser, and ilicic aldehyde, a semi-synthetic sesquiterpene lactones, showed in vivo protection in ethanol-induced gastric mucosa damage. This action was determined by in situ gastric mucosa chemiluminescence and by tissue antioxidant content.
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Cite this article as:
Repetto M.G. and Boveris A., Bioactivity of Sesquiterpenes: Compounds that Protect from Alcohol-Induced Gastric Mucosal Lesions and Oxidative Damage, Mini-Reviews in Medicinal Chemistry 2010; 10 (7) . https://dx.doi.org/10.2174/138955710791383992
DOI https://dx.doi.org/10.2174/138955710791383992 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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