Abstract
A novel series of 2-aryl-1, 2, 4 – triazolo [1, 5-a] pyridine derivatives have been synthesized and evaluated for their cytotoxic activities in vitro against Human ovarian cancer cell line (HO-8910) and Human liver cancer cell line (Bel 7402). Most compounds showed high or mediate activity against the cancer cell lines when compared with Cisplatin. Two of them were tested the apoptosis on Bel 7402.
Keywords: Synthesis, antitumor activity, 2- aryl-1, 2, 4, –, triazolo [1, 5-a] pyridine
Medicinal Chemistry
Title: Synthesis and Antitumor Activity of 2-Aryl-1, 2, 4-Triazolo[1, 5-a] Pyridine Derivatives
Volume: 6 Issue: 2
Author(s): Xuefen Tao and Yongzhou Hu
Affiliation:
Keywords: Synthesis, antitumor activity, 2- aryl-1, 2, 4, –, triazolo [1, 5-a] pyridine
Abstract: A novel series of 2-aryl-1, 2, 4 – triazolo [1, 5-a] pyridine derivatives have been synthesized and evaluated for their cytotoxic activities in vitro against Human ovarian cancer cell line (HO-8910) and Human liver cancer cell line (Bel 7402). Most compounds showed high or mediate activity against the cancer cell lines when compared with Cisplatin. Two of them were tested the apoptosis on Bel 7402.
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Cite this article as:
Tao Xuefen and Hu Yongzhou, Synthesis and Antitumor Activity of 2-Aryl-1, 2, 4-Triazolo[1, 5-a] Pyridine Derivatives, Medicinal Chemistry 2010; 6 (2) . https://dx.doi.org/10.2174/157340610791321505
DOI https://dx.doi.org/10.2174/157340610791321505 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
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