Abstract
It has been recently reported that thiol groups could play an important role in the protection of neuronal cells in Alzheimers disease (AD), prion disease (CJD) and Parkinsons disease (PD). Also bucillamine, that is a pseudo dipeptide possessing a thiol group capable to form an internal disulfide bridge, has relevant scavenger properties used in therapy for the treatment of arthritis. Furthermore, many sulphur containing compounds show strong chelating properties to heavy metals. Due to the crucial role of thiol groups in a variety of detoxicant biological systems, we report the synthesis of a racemic β,β-dialkyl-substituted, fully protected, cysteine derivative as a suitable intermediate in the synthesis of novel biological active peptides.
Keywords: Peptides, peptidomimetic, cysteine, thiols, β,β—dialkyl-amino acids, χ-space
Protein & Peptide Letters
Title: N-(tert)-Butyloxycarbonyl-β,β-Cyclopentyl-Cysteine (Acetamidomethyl)-Methyl Ester for Synthesis of Novel Peptidomimetic Derivatives
Volume: 17 Issue: 7
Author(s): Adriano Mollica, Federica Feliciani, Azzurra Stefanucci, Ivana Cacciatore, Catia Cornacchia, Domenica Torino and Francesco Pinnen
Affiliation:
Keywords: Peptides, peptidomimetic, cysteine, thiols, β,β—dialkyl-amino acids, χ-space
Abstract: It has been recently reported that thiol groups could play an important role in the protection of neuronal cells in Alzheimers disease (AD), prion disease (CJD) and Parkinsons disease (PD). Also bucillamine, that is a pseudo dipeptide possessing a thiol group capable to form an internal disulfide bridge, has relevant scavenger properties used in therapy for the treatment of arthritis. Furthermore, many sulphur containing compounds show strong chelating properties to heavy metals. Due to the crucial role of thiol groups in a variety of detoxicant biological systems, we report the synthesis of a racemic β,β-dialkyl-substituted, fully protected, cysteine derivative as a suitable intermediate in the synthesis of novel biological active peptides.
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Mollica Adriano, Feliciani Federica, Stefanucci Azzurra, Cacciatore Ivana, Cornacchia Catia, Torino Domenica and Pinnen Francesco, N-(tert)-Butyloxycarbonyl-β,β-Cyclopentyl-Cysteine (Acetamidomethyl)-Methyl Ester for Synthesis of Novel Peptidomimetic Derivatives, Protein & Peptide Letters 2010; 17 (7) . https://dx.doi.org/10.2174/092986610791306760
DOI https://dx.doi.org/10.2174/092986610791306760 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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