Synthesis and Biological Evaluation of Novel Bioisosteric Analogues of Dimebon™

Title: Synthesis and Biological Evaluation of Novel Bioisosteric Analogues of Dimebon™

Volume: 7 Issue: 6

Author(s): Alexandre Vasilevich Ivachtchenko, Eugene Borisovich Frolov, Oleg Dmitrievich Mitkin, Sergey Evgenevich Tkachenko and Alexandre Khvat

Affiliation:

Keywords: Dimebon™, Inhibitor, 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole, Alzheimer's disease, Parallel synthesis, GPCR, Analogues

Abstract: In the present paper, we describe the synthesis and biological evaluation for a series of novel 6,9-disubstituted 2-methyl-1,2,3,4,5,6-hexahydroazepino[4,3-b]indoles. These compounds represent unique bioisosteric analogues of Dimebon ™ with promising biological activity against a panel of various targets including some GPCR family members.

Cite this article as:

Vasilevich Ivachtchenko Alexandre, Borisovich Frolov Eugene, Dmitrievich Mitkin Oleg, Evgenevich Tkachenko Sergey and Khvat Alexandre, Synthesis and Biological Evaluation of Novel Bioisosteric Analogues of Dimebon™, Letters in Drug Design & Discovery 2010; 7 (6) . https://dx.doi.org/10.2174/157018010791306579