Abstract
Over the past few years, research in phosphoproteomic has assisted a tremendous revolution thanks to instrumental technologies advances in mass spectrometry combined with innovative experimental strategies. This has allowed the identification of thousands of high confidence phosphosites. Presently, almost 60000 non-redundant phosphosites have been identified from ∼10000 non-redundant proteins and about 80% of these phosphosites have been identified from high throughput experiments in the last six years. The vast majority of phosphosites are still functionally uncharacterized and the kinases responsible of their generation are almost unknown. Several computational approaches have been developed to link kinase families with putative substrates and although these are powerful tools, they are not commonly used. Here we discuss about the present approaches and tools developed for predicting the functional link between the kinases and their substrates.
Keywords: Phosphosites, kinase, predictive programs, consensus sequence
Current Bioinformatics
Title: Matching up Phosphosites to Kinases: A Survey of Available Predictive Programs
Volume: 5 Issue: 2
Author(s): Stefano Toppo, Lorenzo A. Pinna and Mauro Salvi
Affiliation:
Keywords: Phosphosites, kinase, predictive programs, consensus sequence
Abstract: Over the past few years, research in phosphoproteomic has assisted a tremendous revolution thanks to instrumental technologies advances in mass spectrometry combined with innovative experimental strategies. This has allowed the identification of thousands of high confidence phosphosites. Presently, almost 60000 non-redundant phosphosites have been identified from ∼10000 non-redundant proteins and about 80% of these phosphosites have been identified from high throughput experiments in the last six years. The vast majority of phosphosites are still functionally uncharacterized and the kinases responsible of their generation are almost unknown. Several computational approaches have been developed to link kinase families with putative substrates and although these are powerful tools, they are not commonly used. Here we discuss about the present approaches and tools developed for predicting the functional link between the kinases and their substrates.
Export Options
About this article
Cite this article as:
Toppo Stefano, A. Pinna Lorenzo and Salvi Mauro, Matching up Phosphosites to Kinases: A Survey of Available Predictive Programs, Current Bioinformatics 2010; 5 (2) . https://dx.doi.org/10.2174/157489310791268432
DOI https://dx.doi.org/10.2174/157489310791268432 |
Print ISSN 1574-8936 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-392X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Cell Life Versus Cell Longevity: The Mysteries Surrounding the NAD+ Precursor Nicotinamide
Current Medicinal Chemistry Formulation of Nanosuspensions as a New Approach for the Delivery of Poorly Soluble Drugs
Current Nanoscience Research Progress of the UPR Mechanism and its Effect on Improving Foreign Protein Expression
Protein & Peptide Letters A Review of Recent Patents Concerning Therapy of Respiratory Diseases Using Gene Silencing by RNAi (RISC) and EGS (RNAse P)
Recent Patents on Inflammation & Allergy Drug Discovery Progress in Topical siRNA Delivery Approaches for Skin Disorders
Current Pharmaceutical Design Preface [Hot Topic: Antisense (Executive Editor: Michele Sallese) Pages from 769-805]
Current Pharmaceutical Design Structural Elucidation of Unique Inhibitory Activities of Two Thiazolo[ 4,5-d]pyrimidines Against Epidermal Growth Factor Receptor (EGFR): Implications for Successful Drug Design
Medicinal Chemistry Biological Effects, Total Phenolic Content and Flavonoid Concentrations of Fragrant Yellow Onion (Allium flavum L.)
Medicinal Chemistry Inflammation-Mediating Proteases: Structure, Function in (Patho) Physiology and Inhibition
Protein & Peptide Letters Using Small Molecule GSK3β Inhibitors to Treat Inflammation
Current Medicinal Chemistry Pathobiology and Prevention of Cancer Chemotherapy-Induced Bone Growth Arrest, Bone Loss, and Osteonecrosis
Current Molecular Medicine Sulforaphane Treatment of Young Men with Autism Spectrum Disorder
CNS & Neurological Disorders - Drug Targets Prodrugs for Nitroreductase Based Cancer Therapy- 1: Metabolite Profile, Cell Cytotoxicity and Molecular Modeling Interactions of Nitro Benzamides with Ssap-NtrB
Medicinal Chemistry Advances in Peptide Pharmaceuticals
Current Pharmaceutical Biotechnology Extranuclear Localization of SIRT1 and PGC-1α: An Insight into Possible Roles in Diseases Associated with Mitochondrial Dysfunction
Current Molecular Medicine Application of PET to the Diagnosis, Staging, and Treatment of Locally Advanced Non-small Cell Lung Cancer
Current Medical Imaging Neoadjuvant Chemotherapy Before Radical Cystectomy: Why We Must Adhere?
Current Drug Targets Protein Kinase C Isozymes: Memory Therapeutic Potential
Current Drug Targets - CNS & Neurological Disorders Identification of Immunogenic MHC Class II Tyrosinase-Derived Peptides Using HLA-DR1 and HLA-DR4 Transgenic Mice
Protein & Peptide Letters Liposomes: Targeted and Controlled Delivery System
Drug Delivery Letters