Abstract
Allergic rhinitis and asthma are inflammatory airway allergic diseases caused by Th2-driven immune response. Several studies have shown that multipotent adipose-derived stem cells (ASCs) can exert profound immunosuppressive effects via modulation of both cellular and innate immune pathway, especially immunosuppressive effect on T cell activities. ASCs ability to be readily isolated from a number of adipose tissues and expanded ex vivo makes them attractive candidate for use in clinical therapy in the context of allogeneic transplantation, in particular to modulate graft-versus-host disease and graft rejection. The authors have investigated whether ASCs can inhibit Th2-dependent airway allergic disease in the mouse model. In this article we review recent experimental data and discuss about the mechanisms by which ASCs inhibit allergic airway inflammation via immunomodulation from a Th2 to a Th1-biased response in the mouse model.
Keywords: Immunosuppression, adipose tissue, stem cells, asthma, allergic rhinitis
Current Stem Cell Research & Therapy
Title: Immunomodulatory Effects of Adipose-Derived Stem Cells in Airway Allergic Diseases
Volume: 5 Issue: 2
Author(s): Kyu-Sup Cho and Hwan-Jung Roh
Affiliation:
Keywords: Immunosuppression, adipose tissue, stem cells, asthma, allergic rhinitis
Abstract: Allergic rhinitis and asthma are inflammatory airway allergic diseases caused by Th2-driven immune response. Several studies have shown that multipotent adipose-derived stem cells (ASCs) can exert profound immunosuppressive effects via modulation of both cellular and innate immune pathway, especially immunosuppressive effect on T cell activities. ASCs ability to be readily isolated from a number of adipose tissues and expanded ex vivo makes them attractive candidate for use in clinical therapy in the context of allogeneic transplantation, in particular to modulate graft-versus-host disease and graft rejection. The authors have investigated whether ASCs can inhibit Th2-dependent airway allergic disease in the mouse model. In this article we review recent experimental data and discuss about the mechanisms by which ASCs inhibit allergic airway inflammation via immunomodulation from a Th2 to a Th1-biased response in the mouse model.
Export Options
About this article
Cite this article as:
Cho Kyu-Sup and Roh Hwan-Jung, Immunomodulatory Effects of Adipose-Derived Stem Cells in Airway Allergic Diseases, Current Stem Cell Research & Therapy 2010; 5 (2) . https://dx.doi.org/10.2174/157488810791268681
DOI https://dx.doi.org/10.2174/157488810791268681 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Review: Technegas - 99mTc-Metal Core Graphite Nanoparticles for Pulmonary Ventilation Imaging
Current Radiopharmaceuticals A Novel Antidiabetic Therapy: Free Fatty Acid Receptors as Potential Drug Target
Current Diabetes Reviews The Role of Bacterial DNA in Inflammatory and Allergic Disease
Recent Patents on Inflammation & Allergy Drug Discovery Patent Selections:
Recent Patents on Inflammation & Allergy Drug Discovery Advancement in Microbial Cheminformatics
Current Topics in Medicinal Chemistry Insights on the Isolation, Biological Activity and Synthetic Protocols of Enyne Derivatives
Current Topics in Medicinal Chemistry Mouse Models of Asthma: Can They Give Us Mechanistic Insights into the Role of Nitric oxide?
Current Medicinal Chemistry Pharmacogenetics and Anaesthesiology
Current Pharmacogenomics The Immunomodulatory Role of Vitamin D in Respiratory Diseases
Current Respiratory Medicine Reviews Distribution of Macrolide, Lincosamide, Streptogramin, Ketolide and Oxazolidinone (MLSKO) Resistance Genes in Gram-negative Bacteria
Current Drug Targets - Infectious Disorders Liverworts-Potential Source of Medicinal Compounds
Current Pharmaceutical Design Neuropharmacology of Vestibular System Disorders
Current Neuropharmacology An Overview of Non-Neural Sources of Calcitonin Gene-Related Peptide
Current Medicinal Chemistry Recent Development of Drug Delivery Systems for the Treatment of Asthma and Related Disorders
Recent Patents on Inflammation & Allergy Drug Discovery Editorial [Pharmacology and Therapeutic Activity of Purinergic Drugs for Disorders of the Nervous System]
CNS & Neurological Disorders - Drug Targets Preface
Current Drug Targets - Inflammation & Allergy Histamine H4 Receptor: A Novel Therapeutic Target for Immune and Allergic Responses
Mini-Reviews in Medicinal Chemistry A Review of Recent Patents Concerning Therapy of Respiratory Diseases Using Gene Silencing by RNAi (RISC) and EGS (RNAse P)
Recent Patents on Inflammation & Allergy Drug Discovery Combination Therapy with Favipiravir for Treatment of Hospitalized COVID-19 Adults
New Emirates Medical Journal Impurity Profile of Bronchodilators used in Asthma: A Critical Review
Current Drug Discovery Technologies