Abstract
In this review, we discuss the genetic architecture of obesity and the metabolic syndrome, highlighting recent advances in identifying genetic variants and loci responsible for a portion of the variation in components of the metabolic syndrome, namely, adiposity traits, serum HDL and triglycerides, blood pressure, and glycemic traits. We focus particularly on recent progress from large-scale genome-wide association studies (GWAS), by detailing their successes and how lessons learned can pave the way for future discovery. Results from recent GWAS coalesce with earlier work suggesting numerous interconnections between obesity and the metabolic syndrome, developed through several potentially pleiotropic effects. We detail recent work by way of a case study on the cadherin 13 gene and its relation with adiponectin in the HyperGEN and the Framingham Heart Studies, and its association with obesity and the metabolic syndrome. We provide also a gene network analysis of recent variants related to obesity and metabolic syndrome discovered through genome- wide association studies, and 4 gene networks based on searching the NCBI database.
Keywords: Obesity, metabolic syndrome, common complex disease, genetics, GWAS
Endocrine, Metabolic & Immune Disorders - Drug Targets
Title: The Genetics of Obesity and the Metabolic Syndrome
Volume: 10 Issue: 2
Author(s): Keri L. Monda, Kari E. North, Steven C. Hunt, D.C. Rao, Michael A. Province and Aldi T. Kraja
Affiliation:
Keywords: Obesity, metabolic syndrome, common complex disease, genetics, GWAS
Abstract: In this review, we discuss the genetic architecture of obesity and the metabolic syndrome, highlighting recent advances in identifying genetic variants and loci responsible for a portion of the variation in components of the metabolic syndrome, namely, adiposity traits, serum HDL and triglycerides, blood pressure, and glycemic traits. We focus particularly on recent progress from large-scale genome-wide association studies (GWAS), by detailing their successes and how lessons learned can pave the way for future discovery. Results from recent GWAS coalesce with earlier work suggesting numerous interconnections between obesity and the metabolic syndrome, developed through several potentially pleiotropic effects. We detail recent work by way of a case study on the cadherin 13 gene and its relation with adiponectin in the HyperGEN and the Framingham Heart Studies, and its association with obesity and the metabolic syndrome. We provide also a gene network analysis of recent variants related to obesity and metabolic syndrome discovered through genome- wide association studies, and 4 gene networks based on searching the NCBI database.
Export Options
About this article
Cite this article as:
L. Monda Keri, E. North Kari, C. Hunt Steven, Rao D.C., A. Province Michael and T. Kraja Aldi, The Genetics of Obesity and the Metabolic Syndrome, Endocrine, Metabolic & Immune Disorders - Drug Targets 2010; 10 (2) . https://dx.doi.org/10.2174/187153010791213100
DOI https://dx.doi.org/10.2174/187153010791213100 |
Print ISSN 1871-5303 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3873 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Application of Fungal Beta-glucans for the Treatment of Colon Cancer
Anti-Cancer Agents in Medicinal Chemistry INTRODUCTION TO THE ITALIAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS
Endocrine, Metabolic & Immune Disorders - Drug Targets Cholesterol, Copper and Aβ in Controls, MCI, AD and the AD Cholesterol- Lowering Treatment Trial (ADCLT)
Current Alzheimer Research Immunotoxicity and Immunogenicity of Biopharmaceuticals: Design Concepts and Safety Assessment
Current Drug Safety Controlling HIV-1 Rev Function
Current Drug Targets - Immune, Endocrine & Metabolic Disorders Neurodegeneration and Neuroprotection in Multiple Sclerosis
Current Pharmaceutical Design Dopamine and Vascular Dynamics Control: Present Status and Future Perspectives
Current Neurovascular Research 12-Lipoxygenase: A Potential Target for Novel Anti-Platelet Therapeutics
Cardiovascular & Hematological Agents in Medicinal Chemistry Perceived Barriers, Benefits, Facilitators, and Attitudes of Health Professionals Towards Multidisciplinary Team Care in Type 2 Diabetes Management: A Systematic Review
Current Diabetes Reviews Twin-to-Twin Transfusion Syndrome: From Placental Anastomoses to Long-Term Neurodevelopmental Outcome
Current Pediatric Reviews Targeting Growth Factors in Arthritis: A Rational for Restoring the IGF-I Response in Chondrocytes
Current Rheumatology Reviews Drug-Induced Aseptic Meningitis
Current Drug Targets - Immune, Endocrine & Metabolic Disorders Galanin: A Biologically Active Peptide
Current Drug Targets - CNS & Neurological Disorders Overcoming the Skin Permeation Barrier: Challenges and Opportunities
Current Pharmaceutical Design Arterial Stiffness and Cardiovascular Drugs
Current Pharmaceutical Design The Effects of Placental Corticotrophin Releasing Hormone on the Physiology and Psychology of the Pregnant Woman
Current Women`s Health Reviews Pulmonary Valve Endocarditis: A Case Report
Infectious Disorders - Drug Targets Immune-Glutamatergic Dysfunction as a Central Mechanism of the Autism Spectrum Disorders
Current Medicinal Chemistry Astaxanthin and Nrf2 Signaling Pathway: A Novel Target for New Therapeutic Approaches
Mini-Reviews in Medicinal Chemistry CRP Pro-inflammatory Signalling in Atherosclerosis: Myth or Reality?
Current Signal Transduction Therapy