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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Current Review of Small Molecule Ret Kinase Inhibitors

Author(s): W.J. Zuercher, B.J. Turunen and K.E. Lackey

Volume 10, Issue 2, 2010

Page: [138 - 146] Pages: 9

DOI: 10.2174/138955710791185154

Price: $65

Abstract

Aberrant Ret kinase activity has been implicated in multiple carcinomas and disorders. Many strategies have been implemented to identify Ret kinase inhibitors. This review details current efforts to discover novel small molecule Ret kinase inhibitiors. Furthermore, we compile a comprehensive list of Ret kinase inhibitors and describe clinical results of advanced assets with Ret inhibitory activity.

Keywords: Ret kinase, protein tyrosine kinase inhibitors, thyroid cancer


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