Abstract
Risk for Alzheimers disease escalates dramatically with increasing age in the later decades of life. It is widely recognized that a preclinical condition in which memory loss is greater than would be expected for a persons age, referred to as amnestic mild cognitive impairment, may offer the best opportunity for intervention to treat symptoms and modify disease progression. Here we discuss a basis for age-related memory impairment, first discovered in animal models and recently isolated in the medial temporal lobe system of man, that offers a novel entry point for restoring memory function with the possible benefit in slowing progression to Alzheimers disease.
Keywords: Memory, mild cognitive impairment, hippocampus, dentate gyrus/CA3, pattern separation, pattern completion, animal models, neuroimaging
Current Alzheimer Research
Title: Bridging Neurocognitive Aging and Disease Modification: Targeting Functional Mechanisms of Memory Impairment
Volume: 7 Issue: 3
Author(s): M. Gallagher, A. Bakker, M.A. Yassa and C.E.L. Stark
Affiliation:
Keywords: Memory, mild cognitive impairment, hippocampus, dentate gyrus/CA3, pattern separation, pattern completion, animal models, neuroimaging
Abstract: Risk for Alzheimers disease escalates dramatically with increasing age in the later decades of life. It is widely recognized that a preclinical condition in which memory loss is greater than would be expected for a persons age, referred to as amnestic mild cognitive impairment, may offer the best opportunity for intervention to treat symptoms and modify disease progression. Here we discuss a basis for age-related memory impairment, first discovered in animal models and recently isolated in the medial temporal lobe system of man, that offers a novel entry point for restoring memory function with the possible benefit in slowing progression to Alzheimers disease.
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Cite this article as:
Gallagher M., Bakker A., Yassa M.A. and Stark C.E.L., Bridging Neurocognitive Aging and Disease Modification: Targeting Functional Mechanisms of Memory Impairment, Current Alzheimer Research 2010; 7 (3) . https://dx.doi.org/10.2174/156720510791050867
DOI https://dx.doi.org/10.2174/156720510791050867 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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