Abstract
Granulysin is a human polypeptide produced by cytolytic cells active against a broad range of microbes. Three peptides covering the regions 25-50 (Gr-1 and Gr-2) and 39-62 (Gr-3) of granulysin were synthesized, and their in vitro activity against Mycobacterium tuberculosis was evaluated. The most active peptide was Gr-1C, containing a disulphide bridge, with Minimal Inhibitory Concentration value of 10.1 μM. In concentrations of up to 50 μM, Gr-1 and Gr2 didnt exceed 30% of hemolysis.
Keywords: Antimicrobial peptides, Mycobacterium tuberculosis, granulysin, synthetic peptides
Protein & Peptide Letters
Title: Bactericidal and Hemolytic Activities of Synthetic Peptides Derived from Granulysin
Volume: 17 Issue: 4
Author(s): A. Siano, G. Tonarelli, M. S. Imaz, J. C. Perin, N. Ruggeri, M. Lopez, M. N. Santi and E. Zerbini
Affiliation:
Keywords: Antimicrobial peptides, Mycobacterium tuberculosis, granulysin, synthetic peptides
Abstract: Granulysin is a human polypeptide produced by cytolytic cells active against a broad range of microbes. Three peptides covering the regions 25-50 (Gr-1 and Gr-2) and 39-62 (Gr-3) of granulysin were synthesized, and their in vitro activity against Mycobacterium tuberculosis was evaluated. The most active peptide was Gr-1C, containing a disulphide bridge, with Minimal Inhibitory Concentration value of 10.1 μM. In concentrations of up to 50 μM, Gr-1 and Gr2 didnt exceed 30% of hemolysis.
Export Options
About this article
Cite this article as:
Siano A., Tonarelli G., Imaz S. M., Perin C. J., Ruggeri N., Lopez M., Santi N. M. and Zerbini E., Bactericidal and Hemolytic Activities of Synthetic Peptides Derived from Granulysin, Protein & Peptide Letters 2010; 17 (4) . https://dx.doi.org/10.2174/092986610790963555
DOI https://dx.doi.org/10.2174/092986610790963555 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Gold - Old Drug with New Potentials
Current Medicinal Chemistry Organ Preference of Cancer Metastasis and Metastasis-Related Cell Adhesion Molecules Including Carbohydrates
Cardiovascular & Hematological Disorders-Drug Targets Synthesis of Bicyclic Aryl Thiazolines with Selective Anti-Proliferative Effects on Human Cancer Cell Lines
Letters in Organic Chemistry Mechanism(s) Involved in Opioid Drug Abuse Modulation of HAND
Current HIV Research Quinoxaline 1,4-di-N-Oxide Derivatives: Are They Unselective or Selective Inhibitors?
Mini-Reviews in Medicinal Chemistry Metathesis Reactions. General Considerations
Current Topics in Medicinal Chemistry Periodic Correlation Structures in Bacterial and Archaeal Complete Genomes
Current Bioinformatics Anti-infective Potential of Manzamine Alkaloids - A Review
Medicinal Chemistry The Importance of Bioactivation in Computer-Guided Drug Repositioning. Why the Parent Drug is Not Always Enough
Current Topics in Medicinal Chemistry Targeting Tumor Necrosis Factor-α in the Therapy of Psoriasis
Current Drug Targets - Inflammation & Allergy Microwave: An Important and Efficient Tool for the Synthesis of Biological Potent Organic Compounds
Current Medicinal Chemistry Antimicrobial Activity of Phenolics and Glucosinolate Hydrolysis Products and their Synergy with Streptomycin against Pathogenic Bacteria
Medicinal Chemistry Effect of Antitubercular Therapy on Endometrial Function in Infertile Women with Female Genital Tuberculosis
Infectious Disorders - Drug Targets New Agents Promote Neuroprotection in Parkinson’s Disease Models
CNS & Neurological Disorders - Drug Targets The Implication of Pseudomonas aeruginosa Biofilms in Infections
Inflammation & Allergy - Drug Targets (Discontinued) Pre-Clinical Considerations in the Assessment of Immunogenicity for Protein Therapeutics
Current Drug Safety Cytotoxic and Apoptotic Effect of <i>Iris taochia</i> Plant Extracts on Human Breast Cancer (MCF-7) Cells
Current Proteomics Isoniazid: Metabolic Aspects and Toxicological Correlates
Current Drug Metabolism Quinoline Containing Side-chain Antimalarial Analogs: Recent Advances and Therapeutic Application
Current Topics in Medicinal Chemistry Meet Our Editorial Board Member
Infectious Disorders - Drug Targets