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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Synthesis and Cytotoxic Evaluation of Disubstituted N-Acylhydrazones Pyrazinecarbohydrazide Derivatives

Author(s): Marcelle de L. Ferreira, Andre L.P. Candea, Maria das Gracas M. de O. Henriques, Carlos R. Kaiser, Camilo H. da S. Lima and Marcus V.N. de Souza

Volume 7, Issue 4, 2010

Page: [275 - 280] Pages: 6

DOI: 10.2174/157018010790945814

Price: $65

Abstract

A series of seventeen disubstituted N-acylhydrazone pyrazinecarbohydrazide (4-20) have been synthesized and evaluated for their cell viabilities, were compared to another monosubstituted derivatives previously synthesized by us. This study indicated that the position and nature of the substituents in the aromatic ring influence the cytotoxicity of this series.

Keywords: Pyrazine, N-acylhydrazones, Tuberculosis, Drugs


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