A Storage Protein-Like Trypsin Inhibitor from the Moth Bean (Phaseolus acutifolius) with Antiproliferative Activity Toward Lymphoma Cells

Title: A Storage Protein-Like Trypsin Inhibitor from the Moth Bean (Phaseolus acutifolius) with Antiproliferative Activity Toward Lymphoma Cells

Volume: 17 Issue: 6

Author(s): D.Z. Ma, J. Sun, G.Q. Zhang, H.X. Wang and T.B. Ng

Affiliation:

Keywords: antiproliferative, lymphoma cells, moth bean, purification, storage protein, trypsin inhibitor

Abstract: A 26-kDa trypsin inhibitor with an N-terminal sequence resembling storage proteins was purified from moth beans (Phaseolus acutifolius). It dose-dependently inhibited trypsin with an IC50 value of about 0.38 μM. It inhibited [methyl-3H] thymidine incorporation by lymphoma MBL2 cells with an IC50 value of 20 μM.

Cite this article as:

Ma D.Z., Sun J., Zhang G.Q., Wang H.X. and Ng T.B., A Storage Protein-Like Trypsin Inhibitor from the Moth Bean (Phaseolus acutifolius) with Antiproliferative Activity Toward Lymphoma Cells, Protein & Peptide Letters 2010; 17 (6) . https://dx.doi.org/10.2174/092986610791190408