Phenyl and Pyridyl Bis-Pyrazoles: Synthesis from the Bis(β-diketone) Precursors and Characterization by Analytical and Spectroscopic Methods

Title: Phenyl and Pyridyl Bis-Pyrazoles: Synthesis from the Bis(β-diketone) Precursors and Characterization by Analytical and Spectroscopic Methods

Volume: 7 Issue: 2

Author(s): Josefina Pons, Arafa Chadghan, Jordi Garcia-Anton and Josep Ros

Affiliation:

Keywords: Nitrogen heterocycles, bis-pyrazole, bis(β-diketone), NMR spectroscopy

Abstract: The bis(β-diketone) compounds, 3,3-(pyridine-2,6-diyl)bis(1-phenylpropane-1,3-dione) monohydrated (1a H2O) and 3,3-(pyridine-2,6-diyl)bis(1-(pyridin-2-yl)propane-1,3-dione) monohydrated (1b H2O) were prepared by Claisen condensation of the appropriate ketone and dimethyl pyridine-2,6-dicarboxylate ester. Compounds 2,6-bis(5- phenyl-1H-pyrazol-3-yl)pyridine dihydrated (2a 2H2O) and 2,6-bis(5-(pyridin-2-yl)-1H-pyrazol-3-yl)pyridine monohydrated (2b H2O) were synthesized by reaction of the appropriate bis(β-diketone) compounds and hydrazine monohydrate.

Cite this article as:

Pons Josefina, Chadghan Arafa, Garcia-Anton Jordi and Ros Josep, Phenyl and Pyridyl Bis-Pyrazoles: Synthesis from the Bis(β-diketone) Precursors and Characterization by Analytical and Spectroscopic Methods, Letters in Organic Chemistry 2010; 7 (2) . https://dx.doi.org/10.2174/157017810790796273