Synthesis, CI-MS Analyses and Preliminary Biological Evaluation of a Novel Library of Hydrophobic Persulfide-Spacers α-Alkyl Glycosides

Title: Synthesis, CI-MS Analyses and Preliminary Biological Evaluation of a Novel Library of Hydrophobic Persulfide-Spacers α-Alkyl Glycosides

Volume: 7 Issue: 2

Author(s): Hammed H. A.M. Hassan

Affiliation:

Keywords: Carbohydrates, perallyl glycosides, AIBN, sulfide spacer, antimicrobial

Abstract: We report the synthesis of novel polyether-based polyols derived from simple glycosides that bear sulfur spacers in the attempt to potentially provide new antibiotics. The CI-MS demonstrated the stepwise and successive fission of the sulfide-spacer groups; however, it does not distinguish between the alditols having different arrangement of O- (CH2)3-S(CH2)2OH groups. The investigated compounds exhibited antimicrobial activities against Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and antifungal activities against Candida albicans at a concentration of 1 mg / ml in DMF.

Cite this article as:

Hassan A.M. Hammed H., Synthesis, CI-MS Analyses and Preliminary Biological Evaluation of a Novel Library of Hydrophobic Persulfide-Spacers α-Alkyl Glycosides, Letters in Organic Chemistry 2010; 7 (2) . https://dx.doi.org/10.2174/157017810790796372