Synthetic Approaches for Iron Type Chelators

Amaury      du Moulinet d'Hardemare; Guy      Serratrice; Jean-Louis      Pierre

Abstract

Synthetic iron chelators (siderophores mimics) are of paramount interest as clinical iron removal agents (iron overload is one of the most common poisoning) and water-soluble iron complexes can be used to alleviate iron deficiency in plants. Moreover, some additional properties may be needed for a precise function (as examples, probes for studying metal transport, diagnostic tools, agent suited for vectorisation…). We describe in this review the organic syntheses of selected typical examples from our own works. (i) Amphiphilic chelators based on catechol groups. (ii) Mixed ligands based on catechol and quinoline groups. (iii) Quinolobactin, a natural siderophore. (iv) Oxinobactin, a biomimetic synthetic analog of enterobactin involving 8-hydroxyquinoline chelating subunits.

Keywords: Siderophore, catechol, 8-hydroxyquinoline, amphiphiles, tripodal scaffolds, Enterobactin

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Mini-Reviews in Organic Chemistry

Title: Synthetic Approaches for Iron Type Chelators

Volume: 7 Issue: 2

Author(s): Amaury du Moulinet d'Hardemare, Guy Serratrice and Jean-Louis Pierre

Affiliation:

Keywords: Siderophore, catechol, 8-hydroxyquinoline, amphiphiles, tripodal scaffolds, Enterobactin

Abstract: Synthetic iron chelators (siderophores mimics) are of paramount interest as clinical iron removal agents (iron overload is one of the most common poisoning) and water-soluble iron complexes can be used to alleviate iron deficiency in plants. Moreover, some additional properties may be needed for a precise function (as examples, probes for studying metal transport, diagnostic tools, agent suited for vectorisation…). We describe in this review the organic syntheses of selected typical examples from our own works. (i) Amphiphilic chelators based on catechol groups. (ii) Mixed ligands based on catechol and quinoline groups. (iii) Quinolobactin, a natural siderophore. (iv) Oxinobactin, a biomimetic synthetic analog of enterobactin involving 8-hydroxyquinoline chelating subunits.

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du Moulinet d'Hardemare Amaury, Serratrice Guy and Pierre Jean-Louis, Synthetic Approaches for Iron Type Chelators, Mini-Reviews in Organic Chemistry 2010; 7 (2) . https://dx.doi.org/10.2174/157019310791065546

DOI https://dx.doi.org/10.2174/157019310791065546	Print ISSN 1570-193X
Publisher Name Bentham Science Publisher	Online ISSN 1875-6298

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