Abstract
Benchmarking B-cell epitope prediction for vaccine design is meaningful if based on empirical reference data pertaining to cross-reactivities of antipeptide antibodies with native protein antigens; yet it is complicated by such data acquired using antibodies raised against peptide-protein conjugates, as peptide-protein conjugation can differentially suppress antibody responses to peptide epitopes.
Keywords: B-cell epitope prediction, peptide-based vaccine, antipeptide antibody, peptide-protein cross-reactivity, peptideprotein conjugation, structural energetics
Protein & Peptide Letters
Title: Immunization with Peptide-Protein Conjugates: Impact on Benchmarking B-Cell Epitope Prediction for Vaccine Design
Volume: 17 Issue: 3
Author(s): Salvador Eugenio C. Caoili
Affiliation:
Keywords: B-cell epitope prediction, peptide-based vaccine, antipeptide antibody, peptide-protein cross-reactivity, peptideprotein conjugation, structural energetics
Abstract: Benchmarking B-cell epitope prediction for vaccine design is meaningful if based on empirical reference data pertaining to cross-reactivities of antipeptide antibodies with native protein antigens; yet it is complicated by such data acquired using antibodies raised against peptide-protein conjugates, as peptide-protein conjugation can differentially suppress antibody responses to peptide epitopes.
Export Options
About this article
Cite this article as:
Caoili C. Salvador Eugenio, Immunization with Peptide-Protein Conjugates: Impact on Benchmarking B-Cell Epitope Prediction for Vaccine Design, Protein & Peptide Letters 2010; 17 (3) . https://dx.doi.org/10.2174/092986610790780288
DOI https://dx.doi.org/10.2174/092986610790780288 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Berberine Administration in Treatment of Colitis: A Review
Current Drug Targets Editorial [Hot Topic: Modulation and New Mediators in Inflammation Executive (Guest Editor: Frank A. Redegeld)]
Current Pharmaceutical Design Review on Patents for Mechanical Stimulation of Articular Cartilage Tissue Engineering
Recent Patents on Biomedical Engineering (Discontinued) Platelets: Angels and Demons Dancing on the Immune Stage. Nutrition Conducts the Orchestra
Endocrine, Metabolic & Immune Disorders - Drug Targets Sex Differences in Biomarkers for Predicting Cardiovascular and Coronary Events
Current Vascular Pharmacology Another Brick in the Wall: Innate Lymphoid Cells of the Intestine
Current Immunology Reviews (Discontinued) Synthesis, Antitumor Activity, and Structure-activity Relationship of Some Benzo[a]pyrano[2,3-c]phenazine Derivatives
Combinatorial Chemistry & High Throughput Screening Pharmacological Neuroprotective Therapy for Acute Spinal Cord Injury: State of the Art
Mini-Reviews in Medicinal Chemistry Modulation of the Cannabinoid System: A New Perspective for the Treatment of the Alzheimer’s Disease
Current Neuropharmacology Thermodynamic Stability and Flexibility Characteristics of Antibody Fragment Complexes
Protein & Peptide Letters The Immunosuppressive Role of Adenosine A2A Receptors in Ischemia Reperfusion Injury and Islet Transplantation
Current Diabetes Reviews Phosphate-Affinity Gel Electrophoresis Using a Phos-Tag Molecule for Phosphoproteome Study
Current Proteomics Hibiscus Sabdariffa Linnaeus (Malvaceae), Curcumin and Resveratrol as Alternative Medicinal Agents Against Metabolic Syndrome
Cardiovascular & Hematological Agents in Medicinal Chemistry Inhibitors of HDACs - Effective Drugs Against Cancer?
Current Cancer Drug Targets Stem Cells in Kidney Regeneration
Current Medicinal Chemistry Anti-Inflammatory and Antioxidant Properties of a New Arylidene-Thiazolidinedione in Macrophages
Current Medicinal Chemistry Lipid A Biosynthesis of Multidrug-Resistant Pathogens - A Novel Drug Target
Current Pharmaceutical Design Perspective of Molecular Hydrogen in the Treatment of Sepsis
Current Pharmaceutical Design Alzheimer’s Disease: New Concepts on the Role of Autoimmunity and NLRP3 Inflammasome in the Pathogenesis of the Disease
Current Neuropharmacology Endocannabinoid Signaling in the Etiology and Treatment of Major Depressive Illness
Current Pharmaceutical Design