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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Kinetic and Conformational Studies of Adenosine Deaminase Upon Interaction with Oxazepam and Lorazepam

Author(s): A. A. Moosavi-Movahedi, H. Sepassi Tehrani, M. Amanlou, M. N. Soltani Rad, G. H. Hakimelahi, F. Y. Tsai, A. A. Saboury, F. Ahmad, A. Khalafi-Nezhad, N. Poursasan and A. Sharifizadeh

Volume 17, Issue 2, 2010

Page: [197 - 205] Pages: 9

DOI: 10.2174/092986610790226076

Price: $65

Abstract

Oxazepam and lorazepam inhibit the adenosine deaminase (ADA) differently. In the case of lorazepam temperature increment causes an increase in the inhibition potency whereas higher temperature reduces the inhibitory effect of oxazepam; which proposes the overall profounder structural changes in the case of lorazepam relative to those caused by oxazepam.

Keywords: Adenosine deaminase, oxazepam, lorazepam, kinetics, structures


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