Abstract
Certain xenobiotics are given in the “prodrug” form. Either the human body, or one compartment of the body, or the targeted virus itself metabolizes the prodrug into its active form. The bioprecursor form of drugs is used for a wide variety of reasons, namely: to make drug penetration into the target organ (mainly to the brain through the blood-brainbarrier) possible, eliminate unpleasant taste, alter (either increasing or decreasing) the half life of the active component or supply more than one active components to the body.
Keywords: Anticancer, antiviral, bioprecursor, conjugation, medicinal chemistry, phosphate, prodrug
Mini-Reviews in Medicinal Chemistry
Title: Medicinal Chemistry of Antiviral/Anticancer Prodrugs Subjected to Phosphate Conjugation
Volume: 10 Issue: 9
Author(s): H. Kalasz, A. Adem, M.Y. Hasan, E. Adeghate, N. Ram, Z. Gulyas and K. Tekes
Affiliation:
Keywords: Anticancer, antiviral, bioprecursor, conjugation, medicinal chemistry, phosphate, prodrug
Abstract: Certain xenobiotics are given in the “prodrug” form. Either the human body, or one compartment of the body, or the targeted virus itself metabolizes the prodrug into its active form. The bioprecursor form of drugs is used for a wide variety of reasons, namely: to make drug penetration into the target organ (mainly to the brain through the blood-brainbarrier) possible, eliminate unpleasant taste, alter (either increasing or decreasing) the half life of the active component or supply more than one active components to the body.
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Cite this article as:
Kalasz H., Adem A., Hasan M.Y., Adeghate E., Ram N., Gulyas Z. and Tekes K., Medicinal Chemistry of Antiviral/Anticancer Prodrugs Subjected to Phosphate Conjugation, Mini-Reviews in Medicinal Chemistry 2010; 10 (9) . https://dx.doi.org/10.2174/138955710791608307
DOI https://dx.doi.org/10.2174/138955710791608307 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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