Novel Derivatives of 1,3-Dimethyl-5-methylenebarbituric Acid

Title: Novel Derivatives of 1,3-Dimethyl-5-methylenebarbituric Acid

Volume: 6 Issue: 8

Author(s): Kamal Sweidan, Qutaiba Abu-Salem, Ahmed Al-Sheikh and Ghassan Abu Sheikha

Affiliation:

Keywords: 1,3-dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione (1,3-dimethylbarbituric acid), zwitterionic pyridinium adduct, nucleophilic substitution reaction

Abstract: The ability of the pyridinium adduct of 1,3-dimethyl-5-methylenebarbituric acid (2) to undergo nucleophilic substitution reaction has been examined. Various types of nucleophiles, including cyanide, barbiturate, sulfide anions and 1,2-bis(diphenylphosphino)ethane substitute the pyridinium fragment in 2 leading to synthesis of new organic derivatives.

Cite this article as:

Sweidan Kamal, Abu-Salem Qutaiba, Al-Sheikh Ahmed and Sheikha Abu Ghassan, Novel Derivatives of 1,3-Dimethyl-5-methylenebarbituric Acid, Letters in Organic Chemistry 2009; 6 (8) . https://dx.doi.org/10.2174/157017809790442934