Abstract
Pulmonary hypertension in obstructive sleep apnea syndrome is common and under recognized. Although more common in patients with OSA associated with chronic lung disease, it is still present in about 20% of patient without co morbid lung or heart disease. Various pathophysiologic changes in OSA especially nocturnal oxygen desaturation, intrathoracic pressure swings, abnormalities in lung mechanics, alteration in ventricular function and rheological changes can contribute to the presence and severity of pulmonary hypertension. The clinical profile in individuals with OSA and pulmonary hypertension are different than in patients with OSA who do not have pulmonary hypertension. Effective treatment of OSA with n CPAP for 12 weeks results in improvement in pulmonary artery pressure.
Keywords: Sleep and pulmonary hypertension, OSA and pulmonary hypertension, sleep and pathophysiology in pulmonary hypertension, CPAP and pulmonary hypertension
Current Respiratory Medicine Reviews
Title: Sleep in Pulmonary Hypertension
Volume: 5 Issue: 4
Author(s): Siva Ramachandran
Affiliation:
Keywords: Sleep and pulmonary hypertension, OSA and pulmonary hypertension, sleep and pathophysiology in pulmonary hypertension, CPAP and pulmonary hypertension
Abstract: Pulmonary hypertension in obstructive sleep apnea syndrome is common and under recognized. Although more common in patients with OSA associated with chronic lung disease, it is still present in about 20% of patient without co morbid lung or heart disease. Various pathophysiologic changes in OSA especially nocturnal oxygen desaturation, intrathoracic pressure swings, abnormalities in lung mechanics, alteration in ventricular function and rheological changes can contribute to the presence and severity of pulmonary hypertension. The clinical profile in individuals with OSA and pulmonary hypertension are different than in patients with OSA who do not have pulmonary hypertension. Effective treatment of OSA with n CPAP for 12 weeks results in improvement in pulmonary artery pressure.
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Cite this article as:
Ramachandran Siva, Sleep in Pulmonary Hypertension, Current Respiratory Medicine Reviews 2009; 5 (4) . https://dx.doi.org/10.2174/157339809790112474
DOI https://dx.doi.org/10.2174/157339809790112474 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
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