Synthesis and Preliminary Biological Evaluation of Chrysin Derivatives as Potential Anticancer Drugs

Title: Synthesis and Preliminary Biological Evaluation of Chrysin Derivatives as Potential Anticancer Drugs

Volume: 6 Issue: 1

Author(s): Xing Zheng, Fei Fei Zhao, Yun Mei Liu, Xu Yao, Zi Tong Zheng, Xing Luo and Duan Fang Liao

Affiliation:

Abstract: A series of chrysin derivatives were prepared from 2-hydroxyacetophenone, 2,4-dihydroxyacetophenone, 2,4,6- trihydroxy- acetophenone, using modified Baker-Venkataraman transformation. Their anticancer activities in vitro were evaluated by the standard MTT method. The results of biological test showed that some of chrysin derivatives showed stronger anticancer activity than 5-fluorouracil.

Cite this article as:

Zheng Xing, Zhao Fei Fei, Mei Liu Yun, Yao Xu, Zheng Zi Tong, Luo Xing and Liao Duan Fang, Synthesis and Preliminary Biological Evaluation of Chrysin Derivatives as Potential Anticancer Drugs, Medicinal Chemistry 2010; 6 (1) . https://dx.doi.org/10.2174/157340610791208763