Abstract
All living organisms, ranging from microorganisms to plants and mammals, have evolved mechanisms to actively defend themselves against pathogen attack. A wide range of biological activities have been attributed to plant antimicrobial peptides (AMPs) including growth inhibitory effects on a broad range of fungi, Gram-positive and Gram-negative bacteria, viruses, neoplastic cells and parasitic protozoa. Classes of AMPs, their mechanisms of action, biological activity, and cytotoxicity towards host cells are discussed. A particular focus regards AMP candidates with potential for use in defense against biological warfare agents. This field is young, but provides additional stimulus to consideration of these molecules as a new class of therapeutic agents and promises to revolutionize treatment of many infectious diseases.
Keywords: AMPs, novel therapeutic approaches
Current Protein & Peptide Science
Title: Development of Novel Therapeutic Drugs in Humans from Plant Antimicrobial Peptides
Volume: 11 Issue: 3
Author(s): Maira Galdino da Rocha Pitta, Marina Galdino da Rocha Pitta and Suely Lins Galdino
Affiliation:
Keywords: AMPs, novel therapeutic approaches
Abstract: All living organisms, ranging from microorganisms to plants and mammals, have evolved mechanisms to actively defend themselves against pathogen attack. A wide range of biological activities have been attributed to plant antimicrobial peptides (AMPs) including growth inhibitory effects on a broad range of fungi, Gram-positive and Gram-negative bacteria, viruses, neoplastic cells and parasitic protozoa. Classes of AMPs, their mechanisms of action, biological activity, and cytotoxicity towards host cells are discussed. A particular focus regards AMP candidates with potential for use in defense against biological warfare agents. This field is young, but provides additional stimulus to consideration of these molecules as a new class of therapeutic agents and promises to revolutionize treatment of many infectious diseases.
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Cite this article as:
Galdino da Rocha Pitta Maira, Galdino da Rocha Pitta Marina and Lins Galdino Suely, Development of Novel Therapeutic Drugs in Humans from Plant Antimicrobial Peptides, Current Protein & Peptide Science 2010; 11 (3) . https://dx.doi.org/10.2174/138920310791112066
DOI https://dx.doi.org/10.2174/138920310791112066 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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