Anti-Angiogenic Therapy in Renal Cell Carcinoma

Author(s): Shree G. Sharma, Sudip Nanda, Santo Longo.

Journal Name: Recent Patents on Anti-Cancer Drug Discovery

Volume 5 , Issue 1 , 2010

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Abstract:

Renal cell carcinoma (RCC) is one of the most common cancers in the United States. Recent achievements in translational research have lead to significant developments in treatment strategies for this malignancy. RCC is a richly vascular neoplasm. A better understanding of its biology has helped in the development of antiangiogenic therapy. Vascular endothelial growth factor (VEGF) is the most important molecular target in the treatment of RCC. Patents have been filed for anti-VEGF and other molecular pathways involved in the pathogenesis of RCC.

Keywords: Angiogenesis, renal cell carcinoma, VHL, VEGF, sorafenib, sumitinib, bevacizumab, temsirolimus, mTOR, angiopoietins

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Article Details

VOLUME: 5
ISSUE: 1
Year: 2010
Page: [77 - 83]
Pages: 7
DOI: 10.2174/157489210789702181

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