Abstract
Applying RNA interference to silence a specific gene has opened a new and promising avenue of gene therapy. But a key bottleneck is the poor stability and inability of naked siRNA to translocate through cell membranes. Among several delivery systems, cationic peptides capable of penetrating cell membranes have drawn attention due to their structural and functional versatility, potential biocompatibility and ability to target cells. In this review, different classes of peptides employed in siRNA delivery are reviewed. In particular, a new class of siRNA delivery peptides with high transfection efficiency and low cytotoxicity is introduced.
Keywords: RNAi, siRNA, peptide, gene therapy, delivery systems
Current Topics in Medicinal Chemistry
Title: Peptide Mediated siRNA Delivery
Volume: 9 Issue: 12
Author(s): Mousa Jafari and P. Chen
Affiliation:
Keywords: RNAi, siRNA, peptide, gene therapy, delivery systems
Abstract: Applying RNA interference to silence a specific gene has opened a new and promising avenue of gene therapy. But a key bottleneck is the poor stability and inability of naked siRNA to translocate through cell membranes. Among several delivery systems, cationic peptides capable of penetrating cell membranes have drawn attention due to their structural and functional versatility, potential biocompatibility and ability to target cells. In this review, different classes of peptides employed in siRNA delivery are reviewed. In particular, a new class of siRNA delivery peptides with high transfection efficiency and low cytotoxicity is introduced.
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Cite this article as:
Jafari Mousa and Chen P., Peptide Mediated siRNA Delivery, Current Topics in Medicinal Chemistry 2009; 9 (12) . https://dx.doi.org/10.2174/156802609789630839
DOI https://dx.doi.org/10.2174/156802609789630839 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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