Abstract
Microbial transformation of triterpenoids has provided new derivatives that are potentially useful for pharmacological studies. In these biotransformation processes, several reactions that are difficult to achieve by chemical means have been accomplished, such as: introduction of hydroxyl groups into remote positions of the molecules; selective cleavage of the side chains of tetra-cyclic terpenoids to produce C19 steroids; regioselective glycosidic transfer reactions; selective ring cleavage through a Baeyer-Villiger-type oxidation to render seco-triterpenoids; and carbon skeleton rearrangements involving a methyl group migration. These biotransformations have also been used as in vitro models to mimic and predict the mammalian metabolism of biologically active triterpenoids.
Keywords: Microbial transformation, biotransformation, triterpenoid, triterpene, filamentous fungi, bacteria
Call for Papers in Thematic Issues
Navigating the 2D Universe in Organic Chemistry
This special issue explores the transformative impact of two-dimensional (2D) materials on the realm of organic chemistry, unraveling new possibilities for synthesis, functionalization, and applications of organic compounds. Focused on the unique chemistry within this novel dimension, the issue highlights breakthroughs in the field of 2D organic chemistry. Contributions are ...read more
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