Abstract
We analyzed 27 antifungal peptides (AFPs) to understand their stability by various parameters like, stabilization centers, GROMOS, OPLS and FOLDEF force fields. Subsequently, we propose that AFP, NK-Lysin could be considered a potential candidate and also could act as a template for designing the therapeutic peptide drug against pathogenic fungi.
Keywords: NK-Lysin, stabilization centers, total energy, cation-π, intra-molecular interactions, free energy change
Protein & Peptide Letters
Title: Exploring the Structural Stability of a Potential Antifungal Peptide Through Computational Analysis
Volume: 16 Issue: 11
Author(s): R. Rajasekaran and Rao Sethumadhavan
Affiliation:
Keywords: NK-Lysin, stabilization centers, total energy, cation-π, intra-molecular interactions, free energy change
Abstract: We analyzed 27 antifungal peptides (AFPs) to understand their stability by various parameters like, stabilization centers, GROMOS, OPLS and FOLDEF force fields. Subsequently, we propose that AFP, NK-Lysin could be considered a potential candidate and also could act as a template for designing the therapeutic peptide drug against pathogenic fungi.
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Cite this article as:
Rajasekaran R. and Sethumadhavan Rao, Exploring the Structural Stability of a Potential Antifungal Peptide Through Computational Analysis, Protein & Peptide Letters 2009; 16 (11) . https://dx.doi.org/10.2174/092986609789353637
DOI https://dx.doi.org/10.2174/092986609789353637 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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