Design, Synthesis, Crystal Structure and Antitumor Activity of A New Ethyl 3-(quinazolin-4-ylamino)-1H-pyrrole-2-carboxylate Derivative

Title: Design, Synthesis, Crystal Structure and Antitumor Activity of A New Ethyl 3-(quinazolin-4-ylamino)-1H-pyrrole-2-carboxylate Derivative

Volume: 6 Issue: 7

Author(s): Youguang Zheng, Xiaoqing Wu, Min Sun, Liuhai Feng, Mingdong Li and Min Ji

Affiliation:

Keywords: Derivative, Antitumor, Agent, In vitro, Crystal structure, X-ray crystal analysis

Abstract: A new ethyl 3-(quinazolin-4-ylamino)-1H-pyrrole-2-carboxylate derivative has been designed and synthesized as antitumor agent, which was identified by 1HNMR, 13CNMR, IR, MS and EA. The antitumor activity of the new compound was tested against human pancreatic cancer Miacapa2, pancreatic cancer Panc1, prostate cancer DU145 and prostate cancer PC3 cells in vitro, and the target compound crystal structure has been characterized by x-ray crystal analysis.

Cite this article as:

Zheng Youguang, Wu Xiaoqing, Sun Min, Feng Liuhai, Li Mingdong and Ji Min, Design, Synthesis, Crystal Structure and Antitumor Activity of A New Ethyl 3-(quinazolin-4-ylamino)-1H-pyrrole-2-carboxylate Derivative, Letters in Drug Design & Discovery 2009; 6 (7) . https://dx.doi.org/10.2174/157018009789108240