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Current Alzheimer Research

Editor-in-Chief

ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

A Neurotrophic Rationale for the Therapy of Neurodegenerative Disorders

Author(s): H. Uri Saragovi, Edith Hamel and Adriana Di Polo

Volume 6, Issue 5, 2009

Page: [419 - 423] Pages: 5

DOI: 10.2174/156720509789207912

Price: $65

Abstract

The concept and rationale for neuroprotection are presented. Several examples of small molecule neurotrophic agents with favourable drug-like and pharmacological properties are shown. Compound efficacy in acute neurodegenerative models (optic nerve axotomy) and chronic neurodegenerative models (glaucoma, age-associated cognitive impairment, Alzheimers Disease) are evaluated and discussed. Targeting neurotrophin receptors with ligands that activate survival pathways or inhibit death pathways is an alternative worth pursuing.


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