Abstract
Statins used in the treatment of dyslipidemias are top-selling drugs in the world. Economical production of statins in industrial scale is challenging, because the side chain of statins is a 3,5-dihydroxyacid derivative consisting of two asymmetric centers. The most prominent methods for the preparation of the side chain are based on biocatalysis and surveyed in this review.
Keywords: Statin, cardiovascular disease, biocatalysis, dehydrogenase, lipase, haloalcohol dehalogenase, nitrilase, aldolase
Current Organic Synthesis
Title: Biocatalysis in the Preparation of the Statin Side Chain
Volume: 6 Issue: 4
Author(s): Arto Liljeblad, Annukka Kallinen and Liisa T. Kanerva
Affiliation:
Keywords: Statin, cardiovascular disease, biocatalysis, dehydrogenase, lipase, haloalcohol dehalogenase, nitrilase, aldolase
Abstract: Statins used in the treatment of dyslipidemias are top-selling drugs in the world. Economical production of statins in industrial scale is challenging, because the side chain of statins is a 3,5-dihydroxyacid derivative consisting of two asymmetric centers. The most prominent methods for the preparation of the side chain are based on biocatalysis and surveyed in this review.
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Cite this article as:
Liljeblad Arto, Kallinen Annukka and Kanerva T. Liisa, Biocatalysis in the Preparation of the Statin Side Chain, Current Organic Synthesis 2009; 6 (4) . https://dx.doi.org/10.2174/157017909789108738
DOI https://dx.doi.org/10.2174/157017909789108738 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
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Organic synthesis is a fundamental discipline in chemistry, crucial for the creation of complex molecules with diverse applications in pharmaceuticals, materials science, and beyond. However, the process of designing efficient synthetic routes for target molecules remains challenging. Chemical graph theory, a branch of theoretical chemistry, offers powerful tools for understanding ...read more
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