Abstract
New analogues of galanthamine containing peptide fragments either at 6 or 11 position, were synthesized by reaction between galanthamine molecule and dipeptides and tripeptide, derivatives of N-(3,4-dichlorophenyl)-D,L-Ala- OH. The best results according to yields, easily purification of the target products, and simplicity of the scheme realisation was achieved by using of cyanomethyl ester of Boc-Gly-OH as activated compound.
Keywords: Peptides, Galanthamine, Alzheimer's disease, N-(3,4-dichlorophenyl)-D,L-Ala-OH
Protein & Peptide Letters
Title: Synthesis and Characterization of New Galanthamine Derivatives Comprising Peptide Moiety
Volume: 16 Issue: 9
Author(s): Lyubomir T. Vezenkov, Maria G. Georgieva, Dantcho L. Danalev, Tchavdar B. Ivanov and Galya I. Ivanova
Affiliation:
Keywords: Peptides, Galanthamine, Alzheimer's disease, N-(3,4-dichlorophenyl)-D,L-Ala-OH
Abstract: New analogues of galanthamine containing peptide fragments either at 6 or 11 position, were synthesized by reaction between galanthamine molecule and dipeptides and tripeptide, derivatives of N-(3,4-dichlorophenyl)-D,L-Ala- OH. The best results according to yields, easily purification of the target products, and simplicity of the scheme realisation was achieved by using of cyanomethyl ester of Boc-Gly-OH as activated compound.
Export Options
About this article
Cite this article as:
Vezenkov T. Lyubomir, Georgieva G. Maria, Danalev L. Dantcho, Ivanov B. Tchavdar and Ivanova I. Galya, Synthesis and Characterization of New Galanthamine Derivatives Comprising Peptide Moiety, Protein & Peptide Letters 2009; 16 (9) . https://dx.doi.org/10.2174/092986609789055412
DOI https://dx.doi.org/10.2174/092986609789055412 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Application of Monoterpenoids and their Derivatives for Treatment of Neurodegenerative Disorders
Current Medicinal Chemistry Interleukin-18, From Neuroinflammation to Alzheimers Disease
Current Pharmaceutical Design 18F-Labeled 2-Arylquinoline Derivatives for Tau Imaging: Chemical, Radiochemical, Biological and Clinical Features
Current Alzheimer Research Pharmacogenomics in the Intensive Care Unit: Focus on Potential Implications for Clinical Practice
Recent Patents on Biotechnology Editorial [Hot Topic:Perspective on Mild Cognitive Impairment (MCI) (Guest Editor: Bernardino Ghetti)]
Current Alzheimer Research The Integration of the Glutamatergic and the White Matter Hypotheses of Schizophrenias Etiology
Current Neuropharmacology The Origin of Lentivirus Research: Maedi-Visna Virus
Current HIV Research Acknowledgements to Reviewers:
Neuroscience and Biomedical Engineering (Discontinued) The Neurobiological Bases for Development of Pharmacological Treatments of Aggressive Disorders
Current Neuropharmacology Basic Pharmacology of NMDA Receptors
Current Pharmaceutical Design Vasotrophic Regulation of Age-Dependent Hypoxic Cerebrovascular Remodeling
Current Vascular Pharmacology Walnut Extract Inhibits the Fibrillization of Amyloid Beta-Protein, and also Defibrillizes its Preformed Fibrils
Current Alzheimer Research Common Variants in Toll-Like Receptor 4 Confer Susceptibility to Alzheimer’s Disease in a Han Chinese Population
Current Alzheimer Research The Effect of Tele-acupressure Self-practice for Mental Health and Wellbeing in the Community During COVID-19
Current Psychiatry Research and Reviews Cellular Internalization of Quantum Dots Mediated by Cell-Penetrating Peptides
Pharmaceutical Nanotechnology The Fate of Nanocarriers As Nanomedicines In Vivo: Important Considerations and Biological Barriers to Overcome
Current Medicinal Chemistry Recent Progress and Future Directions in Protein-Protein Docking
Current Protein & Peptide Science Drug Targeting to the Brain - A Review
Current Nanoscience The Kynurenine Pathway in the Acute and Chronic Phases of Cerebral Ischemia
Current Pharmaceutical Design miRNAs in Alzheimer Disease – A Therapeutic Perspective
Current Alzheimer Research