Peptoid Analogues of Anoplin Show Antibacterial Activity

K.      Meinike; P.   R.   Hansen

Abstract

We have synthesised nine analogues of the antibacterial peptide anoplin with a peptoid residue at position 5 (HGLLKXIKTLL- NH2). The most active compounds showed MIC-values of 12.5 and 25 μM against E.coli and S.aureus. These MIC-values are comparable with anoplin which showed 23 μM and 11 μM against E.coli and S.aureus. However, the selectivity was reversed. Our results indicate that peptoid analogues of anoplin are promising lead structures for developing new antibacterial agents.

Keywords: Anoplin, antibacterial agents, peptoid, solid-phase synthesis

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Protein & Peptide Letters

Title: Peptoid Analogues of Anoplin Show Antibacterial Activity

Volume: 16 Issue: 9

Author(s): K. Meinike and P. R. Hansen

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Keywords: Anoplin, antibacterial agents, peptoid, solid-phase synthesis

Abstract: We have synthesised nine analogues of the antibacterial peptide anoplin with a peptoid residue at position 5 (HGLLKXIKTLL- NH2). The most active compounds showed MIC-values of 12.5 and 25 μM against E.coli and S.aureus. These MIC-values are comparable with anoplin which showed 23 μM and 11 μM against E.coli and S.aureus. However, the selectivity was reversed. Our results indicate that peptoid analogues of anoplin are promising lead structures for developing new antibacterial agents.

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Meinike K. and Hansen R. P., Peptoid Analogues of Anoplin Show Antibacterial Activity, Protein & Peptide Letters 2009; 16 (9) . https://dx.doi.org/10.2174/092986609789055421