Abstract
The large number of adverse health outcomes associated with advanced paternal age is not widely recognized by the pediatric community. An exploration of the clinical and public health implications of this issue is required so as to develop appropriate policies. Included in this review are the clinically relevant conditions and diseases currently known to be associated with increasing paternal age, including diminutions in child IQ and social function [1], increased rates of low birth weight, certain childhood cancers, autistic spectrum disorders, schizophrenia, achondroplasia, Apert syndrome, Crouzon syndrome, and Multiple Endocrine Neoplasia (MEN). Other conditions for which there may be increased rates, but for which the data are still inconclusive, also are discussed. As men delay childbearing in the developed world, there is a need for pediatricians to be aware of the potential consequences. This paper provides pediatricians with a reference for conditions in children that are related to advanced paternal age, assisting them in maintaining a high index of suspicion, and for use in responding to questions from parents about this issue.
Current Pediatric Reviews
Title: Increased Paternal Age and Child Health and Development
Volume: 5 Issue: 3
Author(s): Samantha Brenner, Karine Kleinhaus, Meredith Kursmark and Michael Weitzman
Affiliation:
Abstract: The large number of adverse health outcomes associated with advanced paternal age is not widely recognized by the pediatric community. An exploration of the clinical and public health implications of this issue is required so as to develop appropriate policies. Included in this review are the clinically relevant conditions and diseases currently known to be associated with increasing paternal age, including diminutions in child IQ and social function [1], increased rates of low birth weight, certain childhood cancers, autistic spectrum disorders, schizophrenia, achondroplasia, Apert syndrome, Crouzon syndrome, and Multiple Endocrine Neoplasia (MEN). Other conditions for which there may be increased rates, but for which the data are still inconclusive, also are discussed. As men delay childbearing in the developed world, there is a need for pediatricians to be aware of the potential consequences. This paper provides pediatricians with a reference for conditions in children that are related to advanced paternal age, assisting them in maintaining a high index of suspicion, and for use in responding to questions from parents about this issue.
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Cite this article as:
Brenner Samantha, Kleinhaus Karine, Kursmark Meredith and Weitzman Michael, Increased Paternal Age and Child Health and Development, Current Pediatric Reviews 2009; 5 (3) . https://dx.doi.org/10.2174/157339609789007178
DOI https://dx.doi.org/10.2174/157339609789007178 |
Print ISSN 1573-3963 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6336 |
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