Abstract
Many snake venom phospholipase A2s (vPLA2s) present biological effects that are independent of hydrolytic activity. Here we review the evidence for the calcium-independent membrane damaging activity of vPLA2s, the possible relevance of this activity on their biological effects, and models for the mechanism of membrane permeabilization by these proteins.
Keywords: Membrane permeabilization, molecular mechanism, micelle nucleation
Protein & Peptide Letters
Title: Calcium-Independent Membrane Damage by Venom Phospholipases A2
Volume: 16 Issue: 8
Author(s): A.H.C. de Oliveira, E. A. Aragao, J. M. Sa, L. Chioato, R. Bugs-Bortoleto, R. Ruller, T. L. Ferreira and R. J. Ward
Affiliation:
Keywords: Membrane permeabilization, molecular mechanism, micelle nucleation
Abstract: Many snake venom phospholipase A2s (vPLA2s) present biological effects that are independent of hydrolytic activity. Here we review the evidence for the calcium-independent membrane damaging activity of vPLA2s, the possible relevance of this activity on their biological effects, and models for the mechanism of membrane permeabilization by these proteins.
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Cite this article as:
de Oliveira A.H.C., Aragao A. E., Sa M. J., Chioato L., Bugs-Bortoleto R., Ruller R., Ferreira L. T. and Ward J. R., Calcium-Independent Membrane Damage by Venom Phospholipases A2, Protein & Peptide Letters 2009; 16 (8) . https://dx.doi.org/10.2174/092986609788923392
DOI https://dx.doi.org/10.2174/092986609788923392 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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