Tandem Generation and Trapping of Furo[3,4-c]isoquinoline Intermediates Leading to the Synthesis of Phenanthridine Ring Systems

Title: Tandem Generation and Trapping of Furo[3,4-c]isoquinoline Intermediates Leading to the Synthesis of Phenanthridine Ring Systems

Volume: 6 Issue: 5

Author(s): Gouranga P. Jana and Binay K. Ghorai

Affiliation:

Keywords: Azaisobenzofuran, carbene complexes, chromium, Diels-Alder reaction, phenanthridine

Abstract: One pot three component coupling of 3-alkynyl-4-isoquinoline carbonyl derivatives with Fischer carbene complexes and dienophiles leading to the synthesis of phenanthridine ring system has been investigated. This reaction involves the generation of furo[3,4-c]isoquinolines as transient intermediates, which undergo [4+2] cycloaddition with a dienophile in an inter/intramolecular fashion. In fact, this is the first report of the work on furo[3,4-c]isoquinoline intermediates.

Cite this article as:

Jana P. Gouranga and Ghorai K. Binay, Tandem Generation and Trapping of Furo[3,4-c]isoquinoline Intermediates Leading to the Synthesis of Phenanthridine Ring Systems, Letters in Organic Chemistry 2009; 6 (5) . https://dx.doi.org/10.2174/157017809788681347