Abstract
The effects of β-cyclodextrin (β-CyD) and trehalose on glycation of human serum albumin (HSA) were studied. These additives reduced AGEs and nanofibril formation of HSA under in vitro glycation conditions and improved its helical structure. These were accomplished through direct interactions of them with HSA and alterations in solute-protein interactions.
Keywords: Diabetes, trehalose, β-cyclodextrin, glycation, HSA, glucose
Protein & Peptide Letters
Title: Inhibitory Effects of β-Cyclodextrin and Trehalose on Nanofibril and AGE Formation During Glycation of Human Serum Albumin
Volume: 16 Issue: 6
Author(s): Esmaeel Sharifi, Naghmeh Sattarahmady, Mehran Habibi-Rezaei, Mohammad Farhadi, Nader Sheibani, Faizan Ahmad and Ali Akbar Moosavi-Movahedi
Affiliation:
Keywords: Diabetes, trehalose, β-cyclodextrin, glycation, HSA, glucose
Abstract: The effects of β-cyclodextrin (β-CyD) and trehalose on glycation of human serum albumin (HSA) were studied. These additives reduced AGEs and nanofibril formation of HSA under in vitro glycation conditions and improved its helical structure. These were accomplished through direct interactions of them with HSA and alterations in solute-protein interactions.
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Sharifi Esmaeel, Sattarahmady Naghmeh, Habibi-Rezaei Mehran, Farhadi Mohammad, Sheibani Nader, Ahmad Faizan and Moosavi-Movahedi Akbar Ali, Inhibitory Effects of β-Cyclodextrin and Trehalose on Nanofibril and AGE Formation During Glycation of Human Serum Albumin, Protein & Peptide Letters 2009; 16 (6) . https://dx.doi.org/10.2174/092986609788490212
DOI https://dx.doi.org/10.2174/092986609788490212 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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