Abstract
Alzheimers disease(AD) is associated with a variety of pathophysiological features, including amyloid plaques, inflammation, immunological changes, cell death and regeneration processes, altered neurotransmission, and agerelated changes. Retinoic acid receptors (RARs) and retinoids are relevant to all of these. Here we review the pathology, pharmacology, and biochemistry of AD in relation to RARs and retinoids, and we suggest that retinoids are candidate drugs for treatment of AD.
Keywords: Alzheimer's disease, retinoid, retinoic acid receptors, inflammation, immunology, regulatory T cell, neurodegeneration
Current Alzheimer Research
Title: Towards Retinoid Therapy for Alzheimers Disease
Volume: 6 Issue: 3
Author(s): K. Shudo, H. Fukasawa, M. Nakagomi and N. Yamagata
Affiliation:
Keywords: Alzheimer's disease, retinoid, retinoic acid receptors, inflammation, immunology, regulatory T cell, neurodegeneration
Abstract: Alzheimers disease(AD) is associated with a variety of pathophysiological features, including amyloid plaques, inflammation, immunological changes, cell death and regeneration processes, altered neurotransmission, and agerelated changes. Retinoic acid receptors (RARs) and retinoids are relevant to all of these. Here we review the pathology, pharmacology, and biochemistry of AD in relation to RARs and retinoids, and we suggest that retinoids are candidate drugs for treatment of AD.
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Cite this article as:
Shudo K., Fukasawa H., Nakagomi M. and Yamagata N., Towards Retinoid Therapy for Alzheimers Disease, Current Alzheimer Research 2009; 6 (3) . https://dx.doi.org/10.2174/156720509788486581
DOI https://dx.doi.org/10.2174/156720509788486581 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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