Synthesis and Biological Evaluation of a Series of 4-(arylamido/imidoalkyl)- 5-(arylideno- 4-oxo-2-thio-imidazolidinyl)-N-(methyl-phenyl-imino) Acridinium Iodides as Potential Antiviral Agents

Title: Synthesis and Biological Evaluation of a Series of 4-(arylamido/imidoalkyl)- 5-(arylideno- 4-oxo-2-thio-imidazolidinyl)-N-(methyl-phenyl-imino) Acridinium Iodides as Potential Antiviral Agents

Volume: 6 Issue: 4

Author(s): Abha Bishnoi, Rashmi Saxena, Suruchi Singh, Archna Rani, M. N. Joshi and S. K. Bajpai

Affiliation:

Keywords: Acridinium iodides, Imidazole, Acetophenones, Amido-alkylated acridines, Anti-JEV activity, Anti HSV-I activity

Abstract: Compounds (5a-5f) containing acridine and imidazole moieties in one molecular union were synthesized, characterized and screened against Japanese Encephalitis virus (JEV) (P 20778) and Herpes Simplex virus type-1 (HSV-1) (753166) in-vitro and in-vivo, both. Compound (5e) exhibited the highest activity against both the test microbe (50% inhibition) while (5a) was moderately active (30% inhibition).Compound (5f) displayed 40% inhibition of HSV-1. Investigation revealed that 2-hydroxyphenyl substituent at position-4 is a key factor for bioactivity.

Cite this article as:

Bishnoi Abha, Saxena Rashmi, Singh Suruchi, Rani Archna, Joshi N. M. and Bajpai K. S., Synthesis and Biological Evaluation of a Series of 4-(arylamido/imidoalkyl)- 5-(arylideno- 4-oxo-2-thio-imidazolidinyl)-N-(methyl-phenyl-imino) Acridinium Iodides as Potential Antiviral Agents, Letters in Drug Design & Discovery 2009; 6 (4) . https://dx.doi.org/10.2174/157018009788452500