Discovery of Novel Plant Peptides as Strong Inhibitors of Metalloproteinases

Title: Discovery of Novel Plant Peptides as Strong Inhibitors of Metalloproteinases

Volume: 16 Issue: 5

Author(s): Dina M. Carrilho, Isabel C. Duarte, Rita Francisco, Candido P.P. Ricardo and Maria C. Duque-Magalhaes

Affiliation:

Keywords: Gelatinase B, lupin quiescent seed, matrixin peptide inhibitor, metalloproteinase protein inhibitor (MPI), thermolysin

Abstract: Five novel metalloproteinase protein inhibitors (MPIs) with molecular mass between 5.6 and 8.9 kDa and acid/neutral pI were detected in lupin seeds and exhibited strong inhibitory activities against thermolysin and/or gelatinase B. These novel peptides constitute not only the first MPIs described in plants but also the first plant peptides with inhibitory activity against a matrixin.

Cite this article as:

Carrilho M. Dina, Duarte C. Isabel, Francisco Rita, Ricardo P.P. Candido and Duque-Magalhaes C. Maria, Discovery of Novel Plant Peptides as Strong Inhibitors of Metalloproteinases, Protein & Peptide Letters 2009; 16 (5) . https://dx.doi.org/10.2174/092986609788167789