Abstract
State-of-the-art biochemistry methods in combination with an automated phenotyping method demonstrate the high potential of transgenic tobacco plants in producing properly-folded therapeutic proteins for the treatment of protein-misfolding diseases (e.g., Alzheimers disease). This molecular farming approach led to highest protein production of hydroponically- grown tobacco compared to other growth substrates generally used in plant cultivation.
Keywords: Protein folding, Alzheimer's disease, molecular farming, PMPs, value-added biochemicals, methodologial strategy
Protein & Peptide Letters
Title: Novel Detection System for Plant Protein Production of Pharmaceuticals and Impact on Conformational Diseases
Volume: 17 Issue: 6
Author(s): Kerstin A. Nagel, Bernd Kastenholz, Frank Gilmer, Ulrich Schurr and Achim Walter
Affiliation:
Keywords: Protein folding, Alzheimer's disease, molecular farming, PMPs, value-added biochemicals, methodologial strategy
Abstract: State-of-the-art biochemistry methods in combination with an automated phenotyping method demonstrate the high potential of transgenic tobacco plants in producing properly-folded therapeutic proteins for the treatment of protein-misfolding diseases (e.g., Alzheimers disease). This molecular farming approach led to highest protein production of hydroponically- grown tobacco compared to other growth substrates generally used in plant cultivation.
Export Options
About this article
Cite this article as:
A. Nagel Kerstin, Kastenholz Bernd, Gilmer Frank, Schurr Ulrich and Walter Achim, Novel Detection System for Plant Protein Production of Pharmaceuticals and Impact on Conformational Diseases, Protein & Peptide Letters 2010; 17 (6) . https://dx.doi.org/10.2174/092986610791190282
DOI https://dx.doi.org/10.2174/092986610791190282 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Oncogenic Role of SET/I2PP2A for Gynecologic Cancers
Current Drug Targets Human Embryonic Stem Cell Therapies for Neurodegenerative Diseases
CNS & Neurological Disorders - Drug Targets Therapy for Dominant Inherited Diseases by Allele-Specific RNA Interference: Successes and Pitfalls
Current Gene Therapy Genetic Determinants of Amyotrophic Lateral Sclerosis as Therapeutic Targets
CNS & Neurological Disorders - Drug Targets Intrinsically Disordered Domains, Amyloids and Protein Liquid Phases: Evolving Concepts and Open Questions
Protein & Peptide Letters Meet Our Editorial Board Member:
Current Alzheimer Research Evaluation of the Performance of Manganese Phthalocyanines as Superoxide Dismutase Mimics
Current Analytical Chemistry Neural Stem Cells: From Neurobiology to Clinical Applications
Current Pharmaceutical Biotechnology Enhanced Action Potential Passage Through the Node of Ranvier of Myelinated Axons via Proton Hopping
Current Computer-Aided Drug Design Current Perspectives of Healthy Mitochondrial Function for Healthy Neurons
Current Drug Targets Drugs of Abuse in Pregnancy, Poor Neonatal Development, and Future Neurodegeneration. Is Oxidative Stress the Culprit?
Current Pharmaceutical Design Polyphenols and Stem Cells for Neuroregeneration in Parkinson’s Disease and Amyotrophic Lateral Sclerosis
Current Pharmaceutical Design Neurorescue Activity, APP Regulation and Amyloid-β Peptide Reduction by Novel Multi-Functional Brain Permeable Iron- Chelating- Antioxidants,M-30 and Green Tea Polyphenol, EGCG
Current Alzheimer Research Emerging Perspectives on DNA Double-strand Breaks in Neurodegenerative Diseases
Current Neuropharmacology Microfluidic Methods for Non-Viral Gene Delivery
Current Gene Therapy Drosophila melanogaster in the Study of Human Neurodegeneration
CNS & Neurological Disorders - Drug Targets Neurological Soft Signs in Patients with Psychosis and Cannabis Abuse: A Systematic Review and Meta-Analysis of Paradox
Current Pharmaceutical Design Prospective Role of Polyphenolic Compounds in the Treatment of Neurodegenerative Diseases
CNS & Neurological Disorders - Drug Targets Functional Characterisation of Homomeric Ionotropic Glutamate Receptors GluR1-GluR6 in a Fluorescence-Based High Throughput Screening Assay
Combinatorial Chemistry & High Throughput Screening Targeting Epigenetics in Nervous System Disease
CNS & Neurological Disorders - Drug Targets