The TPR2B Domain of the Hsp70/Hsp90 Organizing Protein (Hop) May Contribute Towards Its Dimerization

Victoria   M.   Longshaw; Linda   L.   Stephens; Sheril      Daniel; Gregory   L.   Blatch

Abstract

The role of the TPR2B domain of Hop is as yet unknown. We have shown here by site directed mutagenesis and size exclusion chromatography for the first time that the TPR1 and TPR2B domains of Hop independently dimerized, and that the dimerization of TPR2B was not dependent on its predicted two-carboxylate clamp residues. Furthermore, our data indicated that the dimerization of Hop and its domains was not disrupted in the presence of Hsp70 and Hsp90 peptides.

Keywords: Hop, dimerization, tetratricopeptide repeat domain, TPR

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Protein & Peptide Letters

Title: The TPR2B Domain of the Hsp70/Hsp90 Organizing Protein (Hop) May Contribute Towards Its Dimerization

Volume: 16 Issue: 4

Author(s): Victoria M. Longshaw, Linda L. Stephens, Sheril Daniel and Gregory L. Blatch

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Keywords: Hop, dimerization, tetratricopeptide repeat domain, TPR

Abstract: The role of the TPR2B domain of Hop is as yet unknown. We have shown here by site directed mutagenesis and size exclusion chromatography for the first time that the TPR1 and TPR2B domains of Hop independently dimerized, and that the dimerization of TPR2B was not dependent on its predicted two-carboxylate clamp residues. Furthermore, our data indicated that the dimerization of Hop and its domains was not disrupted in the presence of Hsp70 and Hsp90 peptides.

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Longshaw M. Victoria, Stephens L. Linda, Daniel Sheril and Blatch L. Gregory, The TPR2B Domain of the Hsp70/Hsp90 Organizing Protein (Hop) May Contribute Towards Its Dimerization, Protein & Peptide Letters 2009; 16 (4) . https://dx.doi.org/10.2174/092986609787848162