Abstract
In this paper we reported the design, synthesis of a series of thiazolidinedione derivates. Their PPARγ activity in vitro was assessed using a reporter gene assay. In this series, it was demonstrated that compound 8f, 8g and 8h with substituted sulfonamino thiourea groups exhibited significant partial agonistic effects on PPARγ.
Keywords: Diabetes, PPAR, Synthesis, Thiazolidinedione, Sulfonamino thiourea
Letters in Drug Design & Discovery
Title: Design and Synthesis of Thiazolidinedione Derivates as Selective PPARγ Modulators
Volume: 6 Issue: 3
Author(s): Xiangyang Sha, Huibin Zhang, Wenlong Huang, Jinpei Zhou and Yinghong Zhou
Affiliation:
Keywords: Diabetes, PPAR, Synthesis, Thiazolidinedione, Sulfonamino thiourea
Abstract: In this paper we reported the design, synthesis of a series of thiazolidinedione derivates. Their PPARγ activity in vitro was assessed using a reporter gene assay. In this series, it was demonstrated that compound 8f, 8g and 8h with substituted sulfonamino thiourea groups exhibited significant partial agonistic effects on PPARγ.
Export Options
About this article
Cite this article as:
Sha Xiangyang, Zhang Huibin, Huang Wenlong, Zhou Jinpei and Zhou Yinghong, Design and Synthesis of Thiazolidinedione Derivates as Selective PPARγ Modulators, Letters in Drug Design & Discovery 2009; 6 (3) . https://dx.doi.org/10.2174/157018009787847819
DOI https://dx.doi.org/10.2174/157018009787847819 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Integrin Function and Signaling as Pharmacological Targets in Cardiovascular Diseases and in Cancer
Current Pharmaceutical Design Mesenchymal Stem Cells as a Source of Dopaminergic Neurons: A Potential Cell Based Therapy for Parkinson's Disease
Current Stem Cell Research & Therapy Prognostic Parameters for Symptomatic Intracranial Hemorrhage after Intravenous Thrombolysis in Acute Ischemic Stroke in an Asian Population
Current Neurovascular Research Peptidase Inhibitors as a Possible Therapeutic Strategy for Chagas Disease
Current Enzyme Inhibition Mitochondrial Dysfunction in the Pathophysiology of Bipolar Disorder: Effects of Pharmacotherapy
Mini-Reviews in Medicinal Chemistry Long Term Regulation of Cardiac L-Type Calcium Channel by Small G Proteins
Current Medicinal Chemistry Endogenous Retroelements in Cellular Senescence and Related Pathogenic Processes: Promising Drug Targets in Age-Related Diseases
Current Drug Targets Alzheimers Disease Burdens African-Americans: A Review of Epidemiological Risk Factors and Implications for Prevention and Treatment
Current Psychiatry Reviews Targeting the Secretory Pathway for Anti-Inflammatory Drug Development
Current Topics in Medicinal Chemistry Neuroprotective Effects of Quercetin: From Chemistry to Medicine
CNS & Neurological Disorders - Drug Targets Severe Hyponatremia and Other Electrolyte Disturbances Associated with Indapamide
Current Drug Safety MR Spectroscopy in Metabolic Profiling Studies of Stem Cells
Current Medical Imaging Therapeutic Benefits of <i>Piper nigrum</i>: A Review
Current Bioactive Compounds Combination Therapy of Inhaled Corticosteroids and Long-Acting β2- Adrenergics In Management of Patients with Chronic Obstructive Pulmonary Disease
Current Pharmaceutical Design Review of the Third Domain Receptor Binding Fragment of Alphafetoprotein (AFP): Plausible Binding of AFP to Lysophospholipid Receptor Targets
Current Drug Targets Drug Discovery and Design for Complex Diseases through QSAR Computational Methods
Current Pharmaceutical Design Toxicology of Trastuzumab: An Insight into Mechanisms of Cardiotoxicity
Current Cancer Drug Targets Salvia miltiorrhiza: A Potential Red Light to the Development of Cardiovascular Diseases
Current Pharmaceutical Design Dithiocarbamate-based coordination compounds as potent proteasome inhibitors in human cancer cells
Mini-Reviews in Medicinal Chemistry Epigenetics: New Concepts of Old Phenomena in Vascular Physiology
Current Vascular Pharmacology