Abstract
Aromatase is a target of pharmacological interest for the treatment of estrogen-dependent cancers. In an effort to develop new therapies to treat breast cancer, a series of 1-phenethyl-1H-[1,2,4]triazole derivatives (6a-6h) were synthesized and evaluated for their efficacy as aromatase inhibitors. Biological tests suggest that these compounds exhibit mild to moderate inhibitory activity to aromatase.
Keywords: Estrogen, Aromatase inhibitor, Anticancer, Nonsteroidal, Synthesis, 1H-[1,2,4]triazole
Letters in Drug Design & Discovery
Title: Synthesis and Biological Evaluation of Aromatase Inhibitors
Volume: 6 Issue: 3
Author(s): Jinpei Zhou, Huibin Zhang, Hai Qian, Liang Lin, Wenlong Huang and Shuaijian Ni
Affiliation:
Keywords: Estrogen, Aromatase inhibitor, Anticancer, Nonsteroidal, Synthesis, 1H-[1,2,4]triazole
Abstract: Aromatase is a target of pharmacological interest for the treatment of estrogen-dependent cancers. In an effort to develop new therapies to treat breast cancer, a series of 1-phenethyl-1H-[1,2,4]triazole derivatives (6a-6h) were synthesized and evaluated for their efficacy as aromatase inhibitors. Biological tests suggest that these compounds exhibit mild to moderate inhibitory activity to aromatase.
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Cite this article as:
Zhou Jinpei, Zhang Huibin, Qian Hai, Lin Liang, Huang Wenlong and Ni Shuaijian, Synthesis and Biological Evaluation of Aromatase Inhibitors, Letters in Drug Design & Discovery 2009; 6 (3) . https://dx.doi.org/10.2174/157018009787847846
DOI https://dx.doi.org/10.2174/157018009787847846 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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